Age-related changes in central effects of corticotropin-releasing factor (CRF) suggest a role for this mediator in aging anorexia and cachexia

Judit Tenk, Ildikó Rostás, Nóra Füredi, Alexandra Mikó, Margit Solymár, Szilvia Soós, B. Gaszner, Diana Feller, M. Székely, Erika Pétervári, M. Balaskó

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Hypothalamic corticotropin-releasing factor (CRF) lays downstream to catabolic melanocortins and at least partly mediates their catabolic effects. Age-related changes in the melanocortin system (weak responsiveness in middle-aged and a strong one in old rats) have been shown to contribute to middle-aged obesity and later to aging anorexia and cachexia of old age groups. We hypothesized that catabolic (anorexigenic and hypermetabolic) CRF effects vary with aging similarly to those of melanocortins. Thus, we aimed to test whether age-related variations of CRF effects may also contribute to middle-aged obesity and aging anorexia leading to weight loss of old age groups. Food intake, body weight, core temperature, heart rate, and activity were recorded in male Wistar rats of young, middle-aged, aging, and old age groups (from 3 to 24 months) during a 7-day intracerebroventricular CRF infusion (0.2 μg/μl/h) in a biotelemetric system. In addition, CRF gene expression was also assessed by quantitative RT-PCR in the paraventricular nucleus (PVN) of intact animals of the same age groups. The infusion suppressed body weight in the young, aging, and old rats, but not in middle-aged animals. Weak anorexigenic and hypermetabolic effects were detected in the young, whereas strong anorexia (without hypermetabolism) developed in the oldest age groups in which post mortem analysis showed also a reduction of retroperitoneal fat mass. CRF gene expression in the PVN increased with aging. Our results support the potential contribution of age-related changes in CRF effects to aging anorexia and cachexia. The role of the peptide in middle-aged obesity cannot be confirmed.

Original languageEnglish
Pages (from-to)61-72
Number of pages12
JournalGeroScience
Volume39
Issue number1
DOIs
Publication statusPublished - Feb 1 2017

Fingerprint

Cachexia
Corticotropin-Releasing Hormone
Anorexia
Melanocortins
Age Groups
Obesity
Paraventricular Hypothalamic Nucleus
Body Weight
Pituitary Hormone-Releasing Hormones
Gene Expression
Intra-Abdominal Fat
Wistar Rats
Weight Loss
Eating
Heart Rate
Polymerase Chain Reaction
Peptides
Temperature

Keywords

  • Aging
  • Core temperature
  • Corticotropin-releasing factor (CRF)
  • Energy homeostasis
  • Food intake
  • Wistar rat

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

Cite this

Age-related changes in central effects of corticotropin-releasing factor (CRF) suggest a role for this mediator in aging anorexia and cachexia. / Tenk, Judit; Rostás, Ildikó; Füredi, Nóra; Mikó, Alexandra; Solymár, Margit; Soós, Szilvia; Gaszner, B.; Feller, Diana; Székely, M.; Pétervári, Erika; Balaskó, M.

In: GeroScience, Vol. 39, No. 1, 01.02.2017, p. 61-72.

Research output: Contribution to journalArticle

Tenk, Judit ; Rostás, Ildikó ; Füredi, Nóra ; Mikó, Alexandra ; Solymár, Margit ; Soós, Szilvia ; Gaszner, B. ; Feller, Diana ; Székely, M. ; Pétervári, Erika ; Balaskó, M. / Age-related changes in central effects of corticotropin-releasing factor (CRF) suggest a role for this mediator in aging anorexia and cachexia. In: GeroScience. 2017 ; Vol. 39, No. 1. pp. 61-72.
@article{f71c097d1b894ac189b41efc381679f0,
title = "Age-related changes in central effects of corticotropin-releasing factor (CRF) suggest a role for this mediator in aging anorexia and cachexia",
abstract = "Hypothalamic corticotropin-releasing factor (CRF) lays downstream to catabolic melanocortins and at least partly mediates their catabolic effects. Age-related changes in the melanocortin system (weak responsiveness in middle-aged and a strong one in old rats) have been shown to contribute to middle-aged obesity and later to aging anorexia and cachexia of old age groups. We hypothesized that catabolic (anorexigenic and hypermetabolic) CRF effects vary with aging similarly to those of melanocortins. Thus, we aimed to test whether age-related variations of CRF effects may also contribute to middle-aged obesity and aging anorexia leading to weight loss of old age groups. Food intake, body weight, core temperature, heart rate, and activity were recorded in male Wistar rats of young, middle-aged, aging, and old age groups (from 3 to 24 months) during a 7-day intracerebroventricular CRF infusion (0.2 μg/μl/h) in a biotelemetric system. In addition, CRF gene expression was also assessed by quantitative RT-PCR in the paraventricular nucleus (PVN) of intact animals of the same age groups. The infusion suppressed body weight in the young, aging, and old rats, but not in middle-aged animals. Weak anorexigenic and hypermetabolic effects were detected in the young, whereas strong anorexia (without hypermetabolism) developed in the oldest age groups in which post mortem analysis showed also a reduction of retroperitoneal fat mass. CRF gene expression in the PVN increased with aging. Our results support the potential contribution of age-related changes in CRF effects to aging anorexia and cachexia. The role of the peptide in middle-aged obesity cannot be confirmed.",
keywords = "Aging, Core temperature, Corticotropin-releasing factor (CRF), Energy homeostasis, Food intake, Wistar rat",
author = "Judit Tenk and Ildik{\'o} Rost{\'a}s and N{\'o}ra F{\"u}redi and Alexandra Mik{\'o} and Margit Solym{\'a}r and Szilvia So{\'o}s and B. Gaszner and Diana Feller and M. Sz{\'e}kely and Erika P{\'e}terv{\'a}ri and M. Balask{\'o}",
year = "2017",
month = "2",
day = "1",
doi = "10.1007/s11357-017-9962-1",
language = "English",
volume = "39",
pages = "61--72",
journal = "GeroScience",
issn = "2509-2715",
publisher = "Springer International Publishing AG",
number = "1",

}

TY - JOUR

T1 - Age-related changes in central effects of corticotropin-releasing factor (CRF) suggest a role for this mediator in aging anorexia and cachexia

AU - Tenk, Judit

AU - Rostás, Ildikó

AU - Füredi, Nóra

AU - Mikó, Alexandra

AU - Solymár, Margit

AU - Soós, Szilvia

AU - Gaszner, B.

AU - Feller, Diana

AU - Székely, M.

AU - Pétervári, Erika

AU - Balaskó, M.

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Hypothalamic corticotropin-releasing factor (CRF) lays downstream to catabolic melanocortins and at least partly mediates their catabolic effects. Age-related changes in the melanocortin system (weak responsiveness in middle-aged and a strong one in old rats) have been shown to contribute to middle-aged obesity and later to aging anorexia and cachexia of old age groups. We hypothesized that catabolic (anorexigenic and hypermetabolic) CRF effects vary with aging similarly to those of melanocortins. Thus, we aimed to test whether age-related variations of CRF effects may also contribute to middle-aged obesity and aging anorexia leading to weight loss of old age groups. Food intake, body weight, core temperature, heart rate, and activity were recorded in male Wistar rats of young, middle-aged, aging, and old age groups (from 3 to 24 months) during a 7-day intracerebroventricular CRF infusion (0.2 μg/μl/h) in a biotelemetric system. In addition, CRF gene expression was also assessed by quantitative RT-PCR in the paraventricular nucleus (PVN) of intact animals of the same age groups. The infusion suppressed body weight in the young, aging, and old rats, but not in middle-aged animals. Weak anorexigenic and hypermetabolic effects were detected in the young, whereas strong anorexia (without hypermetabolism) developed in the oldest age groups in which post mortem analysis showed also a reduction of retroperitoneal fat mass. CRF gene expression in the PVN increased with aging. Our results support the potential contribution of age-related changes in CRF effects to aging anorexia and cachexia. The role of the peptide in middle-aged obesity cannot be confirmed.

AB - Hypothalamic corticotropin-releasing factor (CRF) lays downstream to catabolic melanocortins and at least partly mediates their catabolic effects. Age-related changes in the melanocortin system (weak responsiveness in middle-aged and a strong one in old rats) have been shown to contribute to middle-aged obesity and later to aging anorexia and cachexia of old age groups. We hypothesized that catabolic (anorexigenic and hypermetabolic) CRF effects vary with aging similarly to those of melanocortins. Thus, we aimed to test whether age-related variations of CRF effects may also contribute to middle-aged obesity and aging anorexia leading to weight loss of old age groups. Food intake, body weight, core temperature, heart rate, and activity were recorded in male Wistar rats of young, middle-aged, aging, and old age groups (from 3 to 24 months) during a 7-day intracerebroventricular CRF infusion (0.2 μg/μl/h) in a biotelemetric system. In addition, CRF gene expression was also assessed by quantitative RT-PCR in the paraventricular nucleus (PVN) of intact animals of the same age groups. The infusion suppressed body weight in the young, aging, and old rats, but not in middle-aged animals. Weak anorexigenic and hypermetabolic effects were detected in the young, whereas strong anorexia (without hypermetabolism) developed in the oldest age groups in which post mortem analysis showed also a reduction of retroperitoneal fat mass. CRF gene expression in the PVN increased with aging. Our results support the potential contribution of age-related changes in CRF effects to aging anorexia and cachexia. The role of the peptide in middle-aged obesity cannot be confirmed.

KW - Aging

KW - Core temperature

KW - Corticotropin-releasing factor (CRF)

KW - Energy homeostasis

KW - Food intake

KW - Wistar rat

UR - http://www.scopus.com/inward/record.url?scp=85017275218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017275218&partnerID=8YFLogxK

U2 - 10.1007/s11357-017-9962-1

DO - 10.1007/s11357-017-9962-1

M3 - Article

C2 - 28299639

AN - SCOPUS:85017275218

VL - 39

SP - 61

EP - 72

JO - GeroScience

JF - GeroScience

SN - 2509-2715

IS - 1

ER -