Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis

Oktavia Tarjanyi, F. Boldizsár, P. Németh, Katalin Mikecz, Tibor T. Glant

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Rheumatoid arthritis (RA) most often begins in females in the fourth-fifth decade of their life, suggesting that the aging of the immune system (immunosenescence) has a major role in this disease. Therefore, in the present study, we sought to investigate the effect of age on arthritis susceptibility in BALB/c mice using the proteoglycan (PG)-induced arthritis (PGIA) model of RA. Results: We have found that young, 1-month-old female BALB/c mice are resistant to the induction of PGIA, but with aging they become susceptible. PG-induced T cell responses decline with age, whereas there is a shift toward Th1 cytokines. An age-dependent decrease in T cell number is associated with an increased ratio of the memory phenotype, and lower CD28 expression. Antigen-presenting cells shifted from macrophages and myeloid dendritic cells in young mice toward B cells in older mice. The regulatory/activated T cell ratio decreases in older mice after PG injections indicating impaired regulation of the immune response. Conclusion: We conclude that immunosenescence could alter arthritis susceptibility in a very complex manner including both adaptive and innate immunities, and it cannot be determined by a single trait. Cumulative alterations in immunoregulatory functions closely resemble human disease, which makes this systemic autoimmune arthritis model of RA even more valuable.

Original languageEnglish
Article number8
JournalImmunity and Ageing
Volume6
DOIs
Publication statusPublished - Jun 11 2009

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Arthritis
Rheumatoid Arthritis
Proteoglycans
T-Lymphocytes
Adaptive Immunity
Antigen-Presenting Cells
Regulatory T-Lymphocytes
Myeloid Cells
Innate Immunity
Dendritic Cells
Immune System
B-Lymphocytes
Cell Count
Macrophages
Cytokines
Phenotype
Injections
Immunosenescence

ASJC Scopus subject areas

  • Immunology
  • Ageing

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Age-related changes in arthritis susceptibility and severity in a murine model of rheumatoid arthritis. / Tarjanyi, Oktavia; Boldizsár, F.; Németh, P.; Mikecz, Katalin; Glant, Tibor T.

In: Immunity and Ageing, Vol. 6, 8, 11.06.2009.

Research output: Contribution to journalArticle

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