Age-related change in the amount of ubiquitinated histones in the mouse brain

Shin ichi Morimoto, Shozo Komatsu, Ryoya Takahashi, Mitsuyoshi Matsuo, Sataro Goto

Research output: Contribution to journalArticle

7 Citations (Scopus)


We investigated age-related changes in the ubiquitination of histones in mouse brains. By Western blot analysis using rabbit anti-ubiquitin antibodies, histone H2A and H2B were found to be the only proteins that are ubiquitinated in the acid-extractable nuclear proteins of both young (4-month-old) and senescent (29-month-old) mouse brains. The proportion of ubiquitinated histones was about 30% higher in senescent mice than in young ones. When total brain homogenates were analyzed similarly using somewhat different age groups of the animals, the proportion in the old animals was about 2-fold higher than that in the young.

Original languageEnglish
Pages (from-to)217-224
Number of pages8
JournalArchives of Gerontology and Geriatrics
Issue number3
Publication statusPublished - Jan 1 1993


  • Aging
  • Mouse brain
  • Ubiquitin
  • Ubiquitinated histone

ASJC Scopus subject areas

  • Health(social science)
  • Ageing
  • Gerontology
  • Geriatrics and Gerontology

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