Age related cellular immune response against complete molar pregnancy

Zoltan Nagymanyoki, David Kindelberger, Rachel Clark, Noah Rodriguez, Vilmos Fulop, Ross S. Berkowitz

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Advanced maternal age may result in a weaker immune response against complete molar pregnancy, therefore increasing the risk of gestational trophoblastic neoplasia due to ineffective elimination of the trophoblastic cells after evacuation. The present study was undertaken to investigate the cellular immune response against complete molar pregnancy at the implantation site in younger and older patients. STUDY DESIGN: Immunolocalization of CD8, granzyme B (GrB), FoxP3 and CD56 was performed on histologic tissue sections prepared from 18 patients aged ≤ 40 years and 10 patients aged > 40 years to characterize effector (GrB+CD8+) cytotoxic T cells, GrB positive and negative natural killer cells (CD56) and regulatory T cells (FoxP3+) at the implantation site in complete molar pregnancies. RESULTS: The number of the different immune cell types did not show significant differences in the implantation sites of complete molar pregnancies between the 2 age groups or between persistent and nonpersistent cases. CONCLUSION: Immunosenescence of the natural killer and T cells most likely does not play a role in the increased incidence of gestational trophoblastic neoplasia in older patients with complete moles.

Original languageEnglish
Pages (from-to)261-266
Number of pages6
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume55
Issue number5-6
Publication statusPublished - May 1 2010

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Keywords

  • Gestational trophoblastic disease
  • Immune response
  • Immunosenescence
  • Maternal age

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Nagymanyoki, Z., Kindelberger, D., Clark, R., Rodriguez, N., Fulop, V., & Berkowitz, R. S. (2010). Age related cellular immune response against complete molar pregnancy. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 55(5-6), 261-266.