Age-related alterations in cardiac response to emotional stress: Relations to behavioral reactivity in the rat

C. Nyakas, Ab J. Alingh Prins, Béla Bohus

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Age and behavioral characteristics are considered as risk factors for disturbances of the cardiac rhythm. Emotional stress may be a disseminating factor. Therefore, cardiac responsiveness and behavioral reactivity and their relation as a function of age have been studied in the rat. Young (3-month-old) and young adult (5-month-old) rats display a relative deceleratory cardiac response with bradyarrhythmias in the initial phase of response to emotional stress evoked by stimuli associated with a previous painful experience. The behavioral response is immobility. The immobility response is also displayed by aged (21-month-old) and senescent (33-month-old) rats but the initial bradycardiac heart response to emotional stress is absent, and the incidence of repetitive extrasystoles is increasing with age. An inverse correlation between behavioral reactivity to novel stimuli and the bradycardiac heart responsiveness is observed in young and young adult individual animals. The behavioral reactivity of the aged and senescent rats is diminished, but the correlation with cardiac reactivity remains preserved. It is suggested that the behaviorally coupled inhibitory influences on the heart are diminishing during aging either due to impairments in the descending cholinergic (vagal) system or secondarily, due to a decrease in the central "drive" of this system.

Original languageEnglish
Pages (from-to)273-280
Number of pages8
JournalPhysiology and Behavior
Volume47
Issue number2
DOIs
Publication statusPublished - 1990

Fingerprint

Psychological Stress
Young Adult
Premature Cardiac Complexes
Bradycardia
Cholinergic Agents
Incidence

Keywords

  • Aging
  • Behavioral reactivity
  • Bradycardia
  • Stress

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

Cite this

Age-related alterations in cardiac response to emotional stress : Relations to behavioral reactivity in the rat. / Nyakas, C.; Alingh Prins, Ab J.; Bohus, Béla.

In: Physiology and Behavior, Vol. 47, No. 2, 1990, p. 273-280.

Research output: Contribution to journalArticle

@article{8673b8ab3f224ad99925b66cd6fc549d,
title = "Age-related alterations in cardiac response to emotional stress: Relations to behavioral reactivity in the rat",
abstract = "Age and behavioral characteristics are considered as risk factors for disturbances of the cardiac rhythm. Emotional stress may be a disseminating factor. Therefore, cardiac responsiveness and behavioral reactivity and their relation as a function of age have been studied in the rat. Young (3-month-old) and young adult (5-month-old) rats display a relative deceleratory cardiac response with bradyarrhythmias in the initial phase of response to emotional stress evoked by stimuli associated with a previous painful experience. The behavioral response is immobility. The immobility response is also displayed by aged (21-month-old) and senescent (33-month-old) rats but the initial bradycardiac heart response to emotional stress is absent, and the incidence of repetitive extrasystoles is increasing with age. An inverse correlation between behavioral reactivity to novel stimuli and the bradycardiac heart responsiveness is observed in young and young adult individual animals. The behavioral reactivity of the aged and senescent rats is diminished, but the correlation with cardiac reactivity remains preserved. It is suggested that the behaviorally coupled inhibitory influences on the heart are diminishing during aging either due to impairments in the descending cholinergic (vagal) system or secondarily, due to a decrease in the central {"}drive{"} of this system.",
keywords = "Aging, Behavioral reactivity, Bradycardia, Stress",
author = "C. Nyakas and {Alingh Prins}, {Ab J.} and B{\'e}la Bohus",
year = "1990",
doi = "10.1016/0031-9384(90)90142-Q",
language = "English",
volume = "47",
pages = "273--280",
journal = "Physiology and Behavior",
issn = "0031-9384",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Age-related alterations in cardiac response to emotional stress

T2 - Relations to behavioral reactivity in the rat

AU - Nyakas, C.

AU - Alingh Prins, Ab J.

AU - Bohus, Béla

PY - 1990

Y1 - 1990

N2 - Age and behavioral characteristics are considered as risk factors for disturbances of the cardiac rhythm. Emotional stress may be a disseminating factor. Therefore, cardiac responsiveness and behavioral reactivity and their relation as a function of age have been studied in the rat. Young (3-month-old) and young adult (5-month-old) rats display a relative deceleratory cardiac response with bradyarrhythmias in the initial phase of response to emotional stress evoked by stimuli associated with a previous painful experience. The behavioral response is immobility. The immobility response is also displayed by aged (21-month-old) and senescent (33-month-old) rats but the initial bradycardiac heart response to emotional stress is absent, and the incidence of repetitive extrasystoles is increasing with age. An inverse correlation between behavioral reactivity to novel stimuli and the bradycardiac heart responsiveness is observed in young and young adult individual animals. The behavioral reactivity of the aged and senescent rats is diminished, but the correlation with cardiac reactivity remains preserved. It is suggested that the behaviorally coupled inhibitory influences on the heart are diminishing during aging either due to impairments in the descending cholinergic (vagal) system or secondarily, due to a decrease in the central "drive" of this system.

AB - Age and behavioral characteristics are considered as risk factors for disturbances of the cardiac rhythm. Emotional stress may be a disseminating factor. Therefore, cardiac responsiveness and behavioral reactivity and their relation as a function of age have been studied in the rat. Young (3-month-old) and young adult (5-month-old) rats display a relative deceleratory cardiac response with bradyarrhythmias in the initial phase of response to emotional stress evoked by stimuli associated with a previous painful experience. The behavioral response is immobility. The immobility response is also displayed by aged (21-month-old) and senescent (33-month-old) rats but the initial bradycardiac heart response to emotional stress is absent, and the incidence of repetitive extrasystoles is increasing with age. An inverse correlation between behavioral reactivity to novel stimuli and the bradycardiac heart responsiveness is observed in young and young adult individual animals. The behavioral reactivity of the aged and senescent rats is diminished, but the correlation with cardiac reactivity remains preserved. It is suggested that the behaviorally coupled inhibitory influences on the heart are diminishing during aging either due to impairments in the descending cholinergic (vagal) system or secondarily, due to a decrease in the central "drive" of this system.

KW - Aging

KW - Behavioral reactivity

KW - Bradycardia

KW - Stress

UR - http://www.scopus.com/inward/record.url?scp=0025265462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025265462&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(90)90142-Q

DO - 10.1016/0031-9384(90)90142-Q

M3 - Article

C2 - 2333342

AN - SCOPUS:0025265462

VL - 47

SP - 273

EP - 280

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

IS - 2

ER -