Age of appearance of circadian rhythm in blood 17-hydroxyprogesterone in 21-hydroxylase deficiency.

Research output: Contribution to journalArticle

Abstract

Sixty-one daily profiles of blood-spot 17-hydroxyprogesterone derived from patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency were analysed to determine the age of appearance of circadian rhythm in hypothalamo-pituitary-adrenal activity. The results revealed that typical circadian adrenocortical rhythm is established at approximately three months after birth. In conclusion, the maturation of supra-hypothalamic brain structure proceeds normally also in humans with constant low level of cortisol in blood.

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalActa physiologica Hungarica
Volume78
Issue number2
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Physiology (medical)

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