Age-dependent susceptibility of adult hippocampal cell proliferation to chronic psychosocial stress

M. Simón, Boldizsár Czéh, Eberhard Fuchs

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Stress inhibits neurogenesis in the adult dentate gyrus. It is not known, however, whether age has any influence on this process. We subjected adult male tree shrews to 5 weeks of psychosocial stress, after which dentate cytogenesis was determined using BrdU immunohistochemistry. We found that older animals were significantly more vulnerable to the adverse effect of stress on dentate cell proliferation.

Original languageEnglish
Pages (from-to)244-248
Number of pages5
JournalBrain Research
Volume1049
Issue number2
DOIs
Publication statusPublished - Jul 12 2005

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Tupaiidae
Neurogenesis
Dentate Gyrus
Bromodeoxyuridine
Immunohistochemistry
Cell Proliferation

Keywords

  • Aging
  • BrdU
  • Hippocampus
  • Neurogenesis
  • Social stress
  • Tree shrew

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Age-dependent susceptibility of adult hippocampal cell proliferation to chronic psychosocial stress. / Simón, M.; Czéh, Boldizsár; Fuchs, Eberhard.

In: Brain Research, Vol. 1049, No. 2, 12.07.2005, p. 244-248.

Research output: Contribution to journalArticle

Simón, M. ; Czéh, Boldizsár ; Fuchs, Eberhard. / Age-dependent susceptibility of adult hippocampal cell proliferation to chronic psychosocial stress. In: Brain Research. 2005 ; Vol. 1049, No. 2. pp. 244-248.
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