Age-dependent role of vasopressin in susceptibility of gastric mucosa to indomethacin-induced injury

D. Zelena, O. Yu Morozova, L. P. Filaretova

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The high prevalence of gastric ulceration underlines the importance of understanding the mechanisms. Based upon its multifactorial role vasopressin (AVP) supposed to be one of the contributory factors however the data are contradictory. The spontaneous AVP-deficient Brattleboro rat seems to be a good tool for studying the role of AVP in physiological processes. However, using adult Brattleboro rats we were unable to confirm any significant effect of AVP deficiency on cold immobilization- and indomethacin-induced ulceration. Although the gastroprotective role of glucocorticoids was confirmed in this strain both with acute dexamethasone pretreatment and adrenalectomy, but AVP deficiency had no influence on indomethacin-induced ulceration in adult rats. While AVP has an age-dependent role in stress hormone regulation and gastric mucosal vulnerability also shows age-dependent alterations, we compared young (4-week-old) rats to old ones (1-year-old). In young rats, the lack of AVP lead to attenuation of indomethacin-induced ulceration, while in old ones in its aggravation. Surprisingly, after refeeding at 4 h we saw the opposite picture: in old rats the AVP deficiency accelerated the healing of indomethacin-induced ulceration, and was protective against intestinal lesions. As AVP is involved in a wide range of physiological processes it may influence a complex process such as ulceration at several central or peripheral points. As the main mechanisms, age-dependent regulation of stress hormone levels and microcirculation could be supposed. Blood glucose levels, prostaglandin E 2 and mucus production as well as regenerative effects may also contribute to the AVP effects. Influence on the circadian clock and mood could also play a role. Taken together, AVP might have dual action on the gastrointestinal tract. A different role could be supposed in young and old populations. On the other hand, AVP may participate differentially in the mechanisms of ulcer formation and healing as well as in the development of gastric and intestinal lesions.

Original languageEnglish
Title of host publicationFrontiers of Gastrointestinal Research
Pages219-229
Number of pages11
Volume30
DOIs
Publication statusPublished - Jun 2012

Publication series

NameFrontiers of Gastrointestinal Research
Volume30
ISSN (Print)03020665
ISSN (Electronic)16623754

Fingerprint

Gastric Mucosa
Vasopressins
Indomethacin
Brattleboro Rats
Physiological Phenomena
Stomach
Wounds and Injuries
Hormones
Circadian Clocks
Adrenalectomy
Mucus
Microcirculation
Prostaglandins E
Immobilization
Dexamethasone
Glucocorticoids
Ulcer
Blood Glucose
Gastrointestinal Tract
Population

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Zelena, D., Morozova, O. Y., & Filaretova, L. P. (2012). Age-dependent role of vasopressin in susceptibility of gastric mucosa to indomethacin-induced injury. In Frontiers of Gastrointestinal Research (Vol. 30, pp. 219-229). (Frontiers of Gastrointestinal Research; Vol. 30). https://doi.org/10.1159/000338458

Age-dependent role of vasopressin in susceptibility of gastric mucosa to indomethacin-induced injury. / Zelena, D.; Morozova, O. Yu; Filaretova, L. P.

Frontiers of Gastrointestinal Research. Vol. 30 2012. p. 219-229 (Frontiers of Gastrointestinal Research; Vol. 30).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Zelena, D, Morozova, OY & Filaretova, LP 2012, Age-dependent role of vasopressin in susceptibility of gastric mucosa to indomethacin-induced injury. in Frontiers of Gastrointestinal Research. vol. 30, Frontiers of Gastrointestinal Research, vol. 30, pp. 219-229. https://doi.org/10.1159/000338458
Zelena D, Morozova OY, Filaretova LP. Age-dependent role of vasopressin in susceptibility of gastric mucosa to indomethacin-induced injury. In Frontiers of Gastrointestinal Research. Vol. 30. 2012. p. 219-229. (Frontiers of Gastrointestinal Research). https://doi.org/10.1159/000338458
Zelena, D. ; Morozova, O. Yu ; Filaretova, L. P. / Age-dependent role of vasopressin in susceptibility of gastric mucosa to indomethacin-induced injury. Frontiers of Gastrointestinal Research. Vol. 30 2012. pp. 219-229 (Frontiers of Gastrointestinal Research).
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