Age-dependent responsiveness of T-lymphocytes to allogeneic and PHA stimulation

C. Onody, G. Batory, G. G. Petranyi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In the course of family investigations a linear age-dependent decrease of reactivity against pooled allogeneic lymphocytes was found between 20 and 70 yr of age. This decreasing tendency was ascertained also by the investigation of unrelated people of a more advanced age. In the elderly, maximal transformation values in PHA stimulation investigated at different PHA doses showed a similar degree of reduction as allogeneic reactivity, and a good correlation between the two parameters of T-lymphocyte function has been found.

Original languageEnglish
Pages (from-to)205-213
Number of pages9
JournalThymus
Volume1
Issue number4-5
Publication statusPublished - Dec 1 1980

ASJC Scopus subject areas

  • Immunology

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