Age-dependent modification of aspecific cellular effects of the benzodiazepine flunitrazepam

Sándor Tóth, István Tarnawa, István Pénzes, Judit Sármány, Z. Tóth

Research output: Contribution to journalArticle

Abstract

The experiments presented here demonstrate an aspecific effect of the benzodiazepine derivative flunitrazepam (FNZ). It differs in sites and mechanisms of action, both from benzodiazepine (BZ) specific effects on gamma-aminobutyric acid (GABA) blocking transmission via central BZ receptors and from BZ effects mediated by peripheral BZ receptors. The aspecific effect of FNZ can suitably be examined on isolated and identified neurons of the mollusc Lymnaea stagnalis (pond snail). The physiological sites of action are outside the synaptic zone, on the neuron somatic membrane and affect 'intrinsic' properties of membrane, including calcium, calcium-activated potassium and chloride channels. The aspecific FNZ effect exerts an influence on the metabolism of the cell by decreasing the permeability of the calcium channel, diminishing the excitability of the neuron membrane, and hyperpolarizing the cell, thus potentiating the specific effect of FNZ. The senile alterations of the neuron function intensify the aspecific effects of FNZ to such a degree that it must be taken seriously in consideration in anesthesia of elderly patients.

Original languageEnglish
Pages (from-to)169-180
Number of pages12
JournalArchives of Gerontology and Geriatrics
Volume18
Issue number3
DOIs
Publication statusPublished - 1994

Fingerprint

Flunitrazepam
Benzodiazepines
Neurons
GABA-A Receptors
Lymnaea
Calcium-Activated Potassium Channels
Chloride Channels
Membranes
Potassium Chloride
Mollusca
Snails
Calcium Channels
gamma-Aminobutyric Acid
Permeability
permeability
Anesthesia
Cell Membrane
Calcium
experiment

Keywords

  • Aging
  • Benzodiazepines
  • Flunitrazepam
  • Lymnaea stagnalis
  • Neuronal membrane
  • Pharmacology non-specific

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

Cite this

Age-dependent modification of aspecific cellular effects of the benzodiazepine flunitrazepam. / Tóth, Sándor; Tarnawa, István; Pénzes, István; Sármány, Judit; Tóth, Z.

In: Archives of Gerontology and Geriatrics, Vol. 18, No. 3, 1994, p. 169-180.

Research output: Contribution to journalArticle

Tóth, Sándor ; Tarnawa, István ; Pénzes, István ; Sármány, Judit ; Tóth, Z. / Age-dependent modification of aspecific cellular effects of the benzodiazepine flunitrazepam. In: Archives of Gerontology and Geriatrics. 1994 ; Vol. 18, No. 3. pp. 169-180.
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