Age-dependent effects of short-term exposure of T-2 toxin or deoxynivalenol on lipid peroxidation and glutathione redox system in broiler chickens

Cs Pelyhe, B. Kövesi, J. Szabó-Fodor, E. Zándoki, M. Erdélyi, B. Kovács, M. Mézes, K. Balogh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose of this study was to investigate the age-dependent, short-term effects of T-2 toxin (5.77 mg T-2 and 1.40 mg HT-2 toxin/kg feed) or deoxynivalenol (DON) (4.86 mg DON and 1.39 mg 15-acetyl-DON/kg feed) in one and three weeks old broiler chicken to observe the changes in parameters of lipid peroxidation, glutathione redox system, and expression of genes related to glutathione redox system in the first 24 h of mycotoxin exposure. Glutathione-redox system responsed to T-2 toxin exposure in both age groups for T-2 toxin in the first 8 h of exposure, while a reactivation was observed in the 3-week-old group after 20 h, although lipid peroxidation did not change significantly. DON did not alter these parameters, only at gene expression level. Gene expression of phospholipid hydroperoxide glutathione peroxidase (GPX4) showed minor, but significant, changes in both age- and mycotoxin exposure groups. Glutathione reductase (GSR) showed a dual response for the mycotoxin exposure, which was not consequent in either age groups, or treatments. Glutathione synthetase (GSS) showed a decreasing tendency in the younger animals while in the older group elevating tendency was observed as effect of both mycotoxins. Time, treatment and their combined effect also showed relation with the changes in the parameters.

Original languageEnglish
Pages (from-to)611-624
Number of pages14
JournalWorld Mycotoxin Journal
Volume11
Issue number4
DOIs
Publication statusPublished - Jan 1 2018

Fingerprint

T-2 Toxin
T-2 toxin
Mycotoxins
phospholipid-hydroperoxide glutathione peroxidase
deoxynivalenol
mycotoxins
Lipid Peroxidation
Oxidation-Reduction
Glutathione
glutathione
Chickens
lipid peroxidation
broiler chickens
Lipids
Gene Expression
Gene expression
gene expression
Glutathione Synthase
Age Groups
glutathione synthase

Keywords

  • Fusarium mycotoxin
  • Gene expression
  • Glutathione redox system
  • Lipid peroxidation

ASJC Scopus subject areas

  • Food Science
  • Toxicology
  • Public Health, Environmental and Occupational Health

Cite this

Age-dependent effects of short-term exposure of T-2 toxin or deoxynivalenol on lipid peroxidation and glutathione redox system in broiler chickens. / Pelyhe, Cs; Kövesi, B.; Szabó-Fodor, J.; Zándoki, E.; Erdélyi, M.; Kovács, B.; Mézes, M.; Balogh, K.

In: World Mycotoxin Journal, Vol. 11, No. 4, 01.01.2018, p. 611-624.

Research output: Contribution to journalArticle

Pelyhe, Cs ; Kövesi, B. ; Szabó-Fodor, J. ; Zándoki, E. ; Erdélyi, M. ; Kovács, B. ; Mézes, M. ; Balogh, K. / Age-dependent effects of short-term exposure of T-2 toxin or deoxynivalenol on lipid peroxidation and glutathione redox system in broiler chickens. In: World Mycotoxin Journal. 2018 ; Vol. 11, No. 4. pp. 611-624.
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