Age dependence of serum β-N-acetylhexosaminidase (NAG) activity

Anna V. Oláh, Robert G. Price, László Csáthy, Éva Országh, E. Oláh, J. Varga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Serum N-acetyl-β-D-glucosaminidase (NAG; EC 3.2.1.30) is a hexosaminidase and may be a predictor of vascular injury, e.g., in infant respiratory distress syndrome, pneumonia, broncho-pulmonary dysplasia and necrotizing enterocolitis. To estimate the new diagnostic prospects we have modified our urinary NAG assay. In this sensitive colorimetric micro-assay, VRA-GlcNAc was used as a substrate. In the present study the age dependence of serum NAG activity was investigated in newborn babies, infants (1-24 months), children (2-18 years) and adults (19-80 years). Serum NAG activity was found to be age-dependent; it is higher in early childhood (11-59 U/l) but decreases to a constant value at the age of 1-2 years. After the age of 2 years it is similar to adults' NAG (10-30 U/l). In pediatrics age-matched reference ranges must be taken into consideration.

Original languageEnglish
Pages (from-to)305-306
Number of pages2
JournalClinical Chemistry and Laboratory Medicine
Volume42
Issue number3
DOIs
Publication statusPublished - 2004

Fingerprint

Hexosaminidases
Assays
Pediatrics
Serum
Newborn Respiratory Distress Syndrome
Necrotizing Enterocolitis
Vascular System Injuries
Pneumonia
Reference Values
Substrates
Newborn Infant
Lung
5-(4-(2-acetamido-2-deoxyglucopyranosyloxy)-3-methoxyphenylmethylene)-2-thioxothiazolidin-4-one-3-ethanoate

Keywords

  • Age dependence
  • Infant respiratory distress syndrome (IRDS)
  • Reference ranges
  • Serum N-acetyl-β-D-glucosaminidase (NAG)
  • Vascular injury
  • VRA-GIcNAc

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Age dependence of serum β-N-acetylhexosaminidase (NAG) activity. / Oláh, Anna V.; Price, Robert G.; Csáthy, László; Országh, Éva; Oláh, E.; Varga, J.

In: Clinical Chemistry and Laboratory Medicine, Vol. 42, No. 3, 2004, p. 305-306.

Research output: Contribution to journalArticle

Oláh, Anna V. ; Price, Robert G. ; Csáthy, László ; Országh, Éva ; Oláh, E. ; Varga, J. / Age dependence of serum β-N-acetylhexosaminidase (NAG) activity. In: Clinical Chemistry and Laboratory Medicine. 2004 ; Vol. 42, No. 3. pp. 305-306.
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