Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise.

Z. Radák, Hae Young Chung, Hisashi Naito, Ryoya Takahashi, Kyung Jin Jung, Hyon Jeen Kim, S. Goto

Research output: Contribution to journalArticle

133 Citations (Scopus)

Abstract

The combined effects of aging and regular physical exercise was investigated on the production of reactive oxygen species (ROS), lipid peroxidation, glutathione status, and the activity of nuclear factor-kappaB (NF-kappaB) in rat liver. A group of 24 male F344 rats was divided into the following categories: adult control (18 months), adult exercised (18 months), and aged control (28 months) and aged exercised (28 months). The ROS formation increased as a function of age and exercise training decreased the rate of ROS formation in the two age groups. Significant positive correlation was found between ROS production and lipid peroxidation (LIPOX). The reduced glutathione (GSH) level was higher and the oxidized glutathione (GSSG) level lower in exercised groups compared with the sedentary controls (P

Original languageEnglish
Pages (from-to)749-750
Number of pages2
JournalFASEB Journal
Volume18
Issue number6
Publication statusPublished - 2004

Fingerprint

Oxidative stress
Liver
Rats
Reactive Oxygen Species
Oxidative Stress
Chemical activation
Exercise
Glutathione Disulfide
Lipid Peroxidation
Glutathione
Lipids
Inbred F344 Rats
Age Groups
Aging of materials

Cite this

Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise. / Radák, Z.; Chung, Hae Young; Naito, Hisashi; Takahashi, Ryoya; Jung, Kyung Jin; Kim, Hyon Jeen; Goto, S.

In: FASEB Journal, Vol. 18, No. 6, 2004, p. 749-750.

Research output: Contribution to journalArticle

Radák, Z. ; Chung, Hae Young ; Naito, Hisashi ; Takahashi, Ryoya ; Jung, Kyung Jin ; Kim, Hyon Jeen ; Goto, S. / Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise. In: FASEB Journal. 2004 ; Vol. 18, No. 6. pp. 749-750.
@article{b420d99439c340a29e39351e801e5a0b,
title = "Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise.",
abstract = "The combined effects of aging and regular physical exercise was investigated on the production of reactive oxygen species (ROS), lipid peroxidation, glutathione status, and the activity of nuclear factor-kappaB (NF-kappaB) in rat liver. A group of 24 male F344 rats was divided into the following categories: adult control (18 months), adult exercised (18 months), and aged control (28 months) and aged exercised (28 months). The ROS formation increased as a function of age and exercise training decreased the rate of ROS formation in the two age groups. Significant positive correlation was found between ROS production and lipid peroxidation (LIPOX). The reduced glutathione (GSH) level was higher and the oxidized glutathione (GSSG) level lower in exercised groups compared with the sedentary controls (P",
author = "Z. Rad{\'a}k and Chung, {Hae Young} and Hisashi Naito and Ryoya Takahashi and Jung, {Kyung Jin} and Kim, {Hyon Jeen} and S. Goto",
year = "2004",
language = "English",
volume = "18",
pages = "749--750",
journal = "FASEB Journal",
issn = "0892-6638",
publisher = "FASEB",
number = "6",

}

TY - JOUR

T1 - Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise.

AU - Radák, Z.

AU - Chung, Hae Young

AU - Naito, Hisashi

AU - Takahashi, Ryoya

AU - Jung, Kyung Jin

AU - Kim, Hyon Jeen

AU - Goto, S.

PY - 2004

Y1 - 2004

N2 - The combined effects of aging and regular physical exercise was investigated on the production of reactive oxygen species (ROS), lipid peroxidation, glutathione status, and the activity of nuclear factor-kappaB (NF-kappaB) in rat liver. A group of 24 male F344 rats was divided into the following categories: adult control (18 months), adult exercised (18 months), and aged control (28 months) and aged exercised (28 months). The ROS formation increased as a function of age and exercise training decreased the rate of ROS formation in the two age groups. Significant positive correlation was found between ROS production and lipid peroxidation (LIPOX). The reduced glutathione (GSH) level was higher and the oxidized glutathione (GSSG) level lower in exercised groups compared with the sedentary controls (P

AB - The combined effects of aging and regular physical exercise was investigated on the production of reactive oxygen species (ROS), lipid peroxidation, glutathione status, and the activity of nuclear factor-kappaB (NF-kappaB) in rat liver. A group of 24 male F344 rats was divided into the following categories: adult control (18 months), adult exercised (18 months), and aged control (28 months) and aged exercised (28 months). The ROS formation increased as a function of age and exercise training decreased the rate of ROS formation in the two age groups. Significant positive correlation was found between ROS production and lipid peroxidation (LIPOX). The reduced glutathione (GSH) level was higher and the oxidized glutathione (GSSG) level lower in exercised groups compared with the sedentary controls (P

UR - http://www.scopus.com/inward/record.url?scp=3042738400&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042738400&partnerID=8YFLogxK

M3 - Article

C2 - 14766800

AN - SCOPUS:3042738400

VL - 18

SP - 749

EP - 750

JO - FASEB Journal

JF - FASEB Journal

SN - 0892-6638

IS - 6

ER -