Age and the associations of living donor and expanded criteria donor kidneys with kidney transplant outcomes

M. Molnár, Elani Streja, Csaba P. Kovesdy, Anuja Shah, Edmund Huang, Suphamai Bunnapradist, Mahesh Krishnan, Joel D. Kopple, Kamyar Kalantar-Zadeh

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: Recent studies show a survival advantage with kidney transplant in elderly patients compared with those on dialysis therapy. Study Design: In our present study, we examined and compared the association of expanded criteria donor (ECD) kidney and living kidney donation with the outcome of kidney transplant across different ages, including elderly recipients. Setting & Participants: Using the Scientific Registry of Transplant Recipients, we identified 145,470 adult kidney transplant patients. Mortality and death-censored transplant failure risks were estimated by Cox proportional regression analyses during follow-up with a median of 3.9 years. Predictors: ECD kidney and living kidney donation and age compared with others. Outcomes: Mortality and death-censored transplant failure risk. Results: Patients were aged 45 ± 16 years and included 40% women and 19% patients with diabetes. Compared with transplant recipients 55 to younger than 65 years, the fully adjusted death-censored transplant failure risk was higher in patients 75 years and older (HR, 1.30; 95% CI, 1.09-1.56), 35 to younger than 55 years (HR, 1.13; 95% CI, 1.08-1.17), and 18 to younger than 35 years (HR, 1.64; 95% CI, 1.57-1.71). Compared with non-ECD kidneys, ECD kidneys were significant predictors of mortality in nonelderly patients (18-

Original languageEnglish
Pages (from-to)841-848
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume59
Issue number6
DOIs
Publication statusPublished - Jun 2012

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Living Donors
Tissue Donors
Transplants
Kidney
Mortality
Registries
Dialysis
Regression Analysis
Survival

Keywords

  • Elderly
  • graft failure
  • kidney transplantation
  • living donor
  • mortality

ASJC Scopus subject areas

  • Nephrology

Cite this

Age and the associations of living donor and expanded criteria donor kidneys with kidney transplant outcomes. / Molnár, M.; Streja, Elani; Kovesdy, Csaba P.; Shah, Anuja; Huang, Edmund; Bunnapradist, Suphamai; Krishnan, Mahesh; Kopple, Joel D.; Kalantar-Zadeh, Kamyar.

In: American Journal of Kidney Diseases, Vol. 59, No. 6, 06.2012, p. 841-848.

Research output: Contribution to journalArticle

Molnár, M, Streja, E, Kovesdy, CP, Shah, A, Huang, E, Bunnapradist, S, Krishnan, M, Kopple, JD & Kalantar-Zadeh, K 2012, 'Age and the associations of living donor and expanded criteria donor kidneys with kidney transplant outcomes', American Journal of Kidney Diseases, vol. 59, no. 6, pp. 841-848. https://doi.org/10.1053/j.ajkd.2011.12.014
Molnár, M. ; Streja, Elani ; Kovesdy, Csaba P. ; Shah, Anuja ; Huang, Edmund ; Bunnapradist, Suphamai ; Krishnan, Mahesh ; Kopple, Joel D. ; Kalantar-Zadeh, Kamyar. / Age and the associations of living donor and expanded criteria donor kidneys with kidney transplant outcomes. In: American Journal of Kidney Diseases. 2012 ; Vol. 59, No. 6. pp. 841-848.
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