Age and monosodium glutamate treatment cause changes in the stimulation-induced [3H]-norepinephrine release from rat nucleus tractus solitarii-dorsal vagal nucleus slices

A. Rónai, Erzsébet Kató, M. Al-Khrasani, Melinda Hajdú, Katalin Müllner, Guy Elor, K. Gyires, S. Fürst, M. Palkóvits

Research output: Contribution to journalArticle

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Abstract

In nucleus tractus solitarii-dorsal vagal nucleus slices prepared from young adult rats (180-260 g) 10-3 M L-glutamate and 10-5 M baclofen caused a 2-3-fold increase of field stimulation-induced [ 3H]-norepinephrine release without affecting the resting release. In slices prepared from rats treated neonatally with monosodium glutamate neither L-glutamate nor baclofen had any effect on stimulation-induced norepinephrine release, tested between postnatal days 74-99 (350-530 g). In untreated littermates used in the same period (460-580 g) L-glutamate was fully effective whereas baclofen was ineffective. The tritium content in tissue extracts did not differ significantly in the three experimental groups. It is concluded that i) the loss of GABAB receptor-mediated disinhibitory stimulation of norepinephrine release is an age-related phenomenon and ii) neonatal monosodium glutamate treatment causes a damage in the local neural circuitry characterized by the loss of glutamate receptor-mediated mechanism that stimulates the release of norepinephrine.

Original languageEnglish
Pages (from-to)1573-1580
Number of pages8
JournalLife Sciences
Volume74
Issue number13
DOIs
Publication statusPublished - Feb 13 2004

Fingerprint

Sodium Glutamate
Solitary Nucleus
Baclofen
Rats
Norepinephrine
Glutamic Acid
Tissue Extracts
Tritium
Glutamate Receptors
Therapeutics
Young Adult

Keywords

  • Baclofen
  • L-glutamate
  • Neonatal monosodium glutamate
  • Norepinephrine release
  • Nucleus tractus solitarii-dorsal motor vagal nucleus
  • Rat age

ASJC Scopus subject areas

  • Pharmacology

Cite this

Age and monosodium glutamate treatment cause changes in the stimulation-induced [3H]-norepinephrine release from rat nucleus tractus solitarii-dorsal vagal nucleus slices. / Rónai, A.; Kató, Erzsébet; Al-Khrasani, M.; Hajdú, Melinda; Müllner, Katalin; Elor, Guy; Gyires, K.; Fürst, S.; Palkóvits, M.

In: Life Sciences, Vol. 74, No. 13, 13.02.2004, p. 1573-1580.

Research output: Contribution to journalArticle

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AU - Al-Khrasani, M.

AU - Hajdú, Melinda

AU - Müllner, Katalin

AU - Elor, Guy

AU - Gyires, K.

AU - Fürst, S.

AU - Palkóvits, M.

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