Age- and gender-related hemorheological alterations in intestinal ischemia-reperfusion in the rat

Anita Mester, Zsuzsanna Magyar, Akos Molnar, Viktoria Somogyi, Bence Tanczos, Katalin Peto, N. Németh

Research output: Contribution to journalArticle


Background: Intestinal ischemia-reperfusion (I/R) is a life-threatening clinical disorder. During I/R, the microrheological parameters of blood (red blood cell deformability and aggregation) worsen, which may contribute to microcirculatory deterioration. Age and gender also have a great influence on hemorheological parameters. We aimed to investigate the gender and age-related microrheological alterations during intestinal I/R. Materials and methods: After the cannulation of the left femoral artery, median laparotomy was performed in Crl:WI rats under general anesthesia. In the young control animals there were no other interventions (female n = 7; male n = 7). In the young (female n = 7; male n = 7) and older I/R groups (female n = 6; male n = 6), the superior mesenteric artery was clipped for 30 min, and a 120-min reperfusion period was observed afterward. Blood samples were taken before and at the 30-min ischemia, in the 30th, 60th, and 120th min of the reperfusion. Hematological parameters, erythrocyte deformability, and aggregation were determined. Results: Hematocrit increased significantly in the younger female I/R group. Red blood cell count was higher in male and older animals. In case of white blood cell count, male animals had higher values compared with females. Platelet count elevated in the younger male and older female I/R animals. Red blood cell deformability worsened, mainly in the male and older I/R groups. Enhanced erythrocyte aggregation was seen in all groups, being more expressed in the female I/R groups. Conclusions: Microrheological parameters show gender and age-related differences during intestinal I/R. These observations have importance in the planning and evaluation of experimental data.

Original languageEnglish
Pages (from-to)68-75
Number of pages8
JournalJournal of Surgical Research
Publication statusPublished - May 1 2018


  • Aging
  • Gender differences
  • Intestinal ischemia-reperfusion
  • Red blood cell aggregation
  • Red blood cell deformability

ASJC Scopus subject areas

  • Surgery

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