After treat-to-target: Can a targeted ultrasound initiative improve RA outcomes?

Richard J. Wakefield, Maria Antonietta D'Agostino, Esperanza Naredo, Maya H. Buch, Annamaria Iagnocco, Lene Terslev, Mikkel Ostergaard, Marina Backhaus, Walter Grassi, Maxime Dougados, Gerd R. Burmester, Benazir Saleem, Eugenio De Miguel, Cristina Estrach, Kei Ikeda, Marwin Gutierrez, Robert Thompson, Peter Balint, Paul Emery

Research output: Contribution to journalReview article

82 Citations (Scopus)


For patients with rheumatoid arthritis (RA), remission can be achieved with tight control of inflammation and early use of disease modifying agents. The importance of remission as an outcome has been recently highlighted by European League Against Rheumatism recommendations. However, remission when defined by clinical remission criteria (disease activity score, simplified disease activity index, etc) does not always equate to the complete absence of inflammation as measured by new sensitive imaging techniques such as ultrasound (US) . There is evidence that imaging synovitis is frequently found in these patients and associated with adverse clinical and functional outcomes. This article reviews the data regarding remission, ultrasound imaging and outcomes in patients with RA to provide the background to a consensus statement from an international collaboration of ultrasonographers and rheumatologists who have recently formed a research network - the Targeted Ultrasound Initiative (TUI) group. The statement proposes that targeting therapy to PD activity provides superior outcomes compared with treating to clinical targets alone and introduces the rationale for a new randomised trial using targeted ultrasound in RA.

Original languageEnglish
Pages (from-to)799-803
Number of pages5
JournalAnnals of the rheumatic diseases
Issue number6
Publication statusPublished - Jun 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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    Wakefield, R. J., D'Agostino, M. A., Naredo, E., Buch, M. H., Iagnocco, A., Terslev, L., Ostergaard, M., Backhaus, M., Grassi, W., Dougados, M., Burmester, G. R., Saleem, B., De Miguel, E., Estrach, C., Ikeda, K., Gutierrez, M., Thompson, R., Balint, P., & Emery, P. (2012). After treat-to-target: Can a targeted ultrasound initiative improve RA outcomes? Annals of the rheumatic diseases, 71(6), 799-803.