Affinity labeling of opioid receptors with enkephalin analogues

A. Borsodi, H. A. Oktem, S. Benyhe, E. Varga, J. Moitra, J. Takacs

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Chloromethyl ketone derivatives of enkephalins and Tyr-D-Ala-Gly(Me)Phe-Gly-ol (DAGO) were synthesized in normal and in tritiated form and were shown to react irreversibly at opioid receptors. Affinity of the chloromethyl ketone derivatives toward the μ site is greater than that of the parent compounds. It was shown in several studies (including autoradiography) with these ligands that the μ receptor protein contains only one type of binding subunit whose apparent M(r) is 58000.

Original languageEnglish
Title of host publicationNew leads in opioid research
Subtitle of host publicationproceedings of the International Narcotics Research Conference. ICS914
EditorsJ.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
PublisherElsevier Science Publishers B.V.
Number of pages1
ISBN (Print)044481213X
Publication statusPublished - Jan 1 1990
EventThe International Narcotics Research Conference -
Duration: Jul 8 1989Jul 13 1989

Publication series

NameNew leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914

Other

OtherThe International Narcotics Research Conference
Period7/8/897/13/89

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Borsodi, A., Oktem, H. A., Benyhe, S., Varga, E., Moitra, J., & Takacs, J. (1990). Affinity labeling of opioid receptors with enkephalin analogues. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, T. B. Van Wimersma Greidanus, J. M. Van Ree, A. H. Mulder, V. M. Wiegant, & T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914 (New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914). Elsevier Science Publishers B.V..