Affective temperamental profiles are associated with white matter hyperintensity and suicidal risk in patients with mood disorders

Gianluca Serafini, Maurizio Pompili, Marco Innamorati, Paolo Fusar-Poli, Hagop S. Akiskal, Z. Ríhmer, David Lester, Andrea Romano, Irismar Reis De Oliveira, Leonardo Strusi, Stefano Ferracuti, Paolo Girardi, Roberto Tatarelli

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Background: Patients with white matter hyperintensities (WMH) may be at higher risk for affective disorders and suicide. Affective temperaments may play a significant role in mood disorders. This study aimed to evaluate the eventual association between WMH, affective temperaments and suicidal behaviour in major affective disorder. Methods: A total of 318 patients with major affective disorders were consecutively admitted as psychiatric inpatient. A total of 247 were included and given, brain magnetic resonance imaging (MRI) and assessed with the Mini International Neuropsychiatric Interview (MINI), the Beck Hopelessness Scale (BHS), the Hamilton Depression Rating Scale (HDRS 17), the Young Mania Rating Scale (YMRS) and the Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS-A). Results: A total of 48% of patients had periventricular WMH (PWMH) and 39% of them had deep WMH (DWMH). Patients with higher dysthymia and lower hyperthymia (H-DCIA group) were more likely to have higher BHS scores (BHS ≥ 9 = 77% vs. 52%; p > 0.001), more WMH (46% vs. 29%; χ2 n = 3 = 9.90; p <0.05), higher MINI suicidal risk (54% vs. 42%; p <0.05), and more recent suicide attempts (24% vs. 14%; p <0.05), than patients with higher hyperthymia and lower dysthymia (H-H group). Limitations: The small sample size did not allow the generalization of the present findings. Conclusions: Differences among temperament groups measured by the TEMPS-A are associated with differences in their MRIs, indicating that different temperament profiles are associated with differences in the subcortical structures of the brain. The implications of the results were discussed.

Original languageEnglish
Pages (from-to)47-55
Number of pages9
JournalJournal of Affective Disorders
Volume129
Issue number1-3
DOIs
Publication statusPublished - Mar 2011

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Temperament
Mood Disorders
Paris
Suicide
Brain
Bipolar Disorder
Sample Size
Psychiatry
White Matter
Inpatients
Magnetic Resonance Imaging
Interviews
Depression

Keywords

  • Affective temperaments
  • DWMH
  • Mood disorders
  • MRI
  • PWMH
  • Suicidal risk

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

Affective temperamental profiles are associated with white matter hyperintensity and suicidal risk in patients with mood disorders. / Serafini, Gianluca; Pompili, Maurizio; Innamorati, Marco; Fusar-Poli, Paolo; Akiskal, Hagop S.; Ríhmer, Z.; Lester, David; Romano, Andrea; De Oliveira, Irismar Reis; Strusi, Leonardo; Ferracuti, Stefano; Girardi, Paolo; Tatarelli, Roberto.

In: Journal of Affective Disorders, Vol. 129, No. 1-3, 03.2011, p. 47-55.

Research output: Contribution to journalArticle

Serafini, G, Pompili, M, Innamorati, M, Fusar-Poli, P, Akiskal, HS, Ríhmer, Z, Lester, D, Romano, A, De Oliveira, IR, Strusi, L, Ferracuti, S, Girardi, P & Tatarelli, R 2011, 'Affective temperamental profiles are associated with white matter hyperintensity and suicidal risk in patients with mood disorders', Journal of Affective Disorders, vol. 129, no. 1-3, pp. 47-55. https://doi.org/10.1016/j.jad.2010.07.020
Serafini, Gianluca ; Pompili, Maurizio ; Innamorati, Marco ; Fusar-Poli, Paolo ; Akiskal, Hagop S. ; Ríhmer, Z. ; Lester, David ; Romano, Andrea ; De Oliveira, Irismar Reis ; Strusi, Leonardo ; Ferracuti, Stefano ; Girardi, Paolo ; Tatarelli, Roberto. / Affective temperamental profiles are associated with white matter hyperintensity and suicidal risk in patients with mood disorders. In: Journal of Affective Disorders. 2011 ; Vol. 129, No. 1-3. pp. 47-55.
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abstract = "Background: Patients with white matter hyperintensities (WMH) may be at higher risk for affective disorders and suicide. Affective temperaments may play a significant role in mood disorders. This study aimed to evaluate the eventual association between WMH, affective temperaments and suicidal behaviour in major affective disorder. Methods: A total of 318 patients with major affective disorders were consecutively admitted as psychiatric inpatient. A total of 247 were included and given, brain magnetic resonance imaging (MRI) and assessed with the Mini International Neuropsychiatric Interview (MINI), the Beck Hopelessness Scale (BHS), the Hamilton Depression Rating Scale (HDRS 17), the Young Mania Rating Scale (YMRS) and the Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS-A). Results: A total of 48{\%} of patients had periventricular WMH (PWMH) and 39{\%} of them had deep WMH (DWMH). Patients with higher dysthymia and lower hyperthymia (H-DCIA group) were more likely to have higher BHS scores (BHS ≥ 9 = 77{\%} vs. 52{\%}; p > 0.001), more WMH (46{\%} vs. 29{\%}; χ2 n = 3 = 9.90; p <0.05), higher MINI suicidal risk (54{\%} vs. 42{\%}; p <0.05), and more recent suicide attempts (24{\%} vs. 14{\%}; p <0.05), than patients with higher hyperthymia and lower dysthymia (H-H group). Limitations: The small sample size did not allow the generalization of the present findings. Conclusions: Differences among temperament groups measured by the TEMPS-A are associated with differences in their MRIs, indicating that different temperament profiles are associated with differences in the subcortical structures of the brain. The implications of the results were discussed.",
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AU - Pompili, Maurizio

AU - Innamorati, Marco

AU - Fusar-Poli, Paolo

AU - Akiskal, Hagop S.

AU - Ríhmer, Z.

AU - Lester, David

AU - Romano, Andrea

AU - De Oliveira, Irismar Reis

AU - Strusi, Leonardo

AU - Ferracuti, Stefano

AU - Girardi, Paolo

AU - Tatarelli, Roberto

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N2 - Background: Patients with white matter hyperintensities (WMH) may be at higher risk for affective disorders and suicide. Affective temperaments may play a significant role in mood disorders. This study aimed to evaluate the eventual association between WMH, affective temperaments and suicidal behaviour in major affective disorder. Methods: A total of 318 patients with major affective disorders were consecutively admitted as psychiatric inpatient. A total of 247 were included and given, brain magnetic resonance imaging (MRI) and assessed with the Mini International Neuropsychiatric Interview (MINI), the Beck Hopelessness Scale (BHS), the Hamilton Depression Rating Scale (HDRS 17), the Young Mania Rating Scale (YMRS) and the Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS-A). Results: A total of 48% of patients had periventricular WMH (PWMH) and 39% of them had deep WMH (DWMH). Patients with higher dysthymia and lower hyperthymia (H-DCIA group) were more likely to have higher BHS scores (BHS ≥ 9 = 77% vs. 52%; p > 0.001), more WMH (46% vs. 29%; χ2 n = 3 = 9.90; p <0.05), higher MINI suicidal risk (54% vs. 42%; p <0.05), and more recent suicide attempts (24% vs. 14%; p <0.05), than patients with higher hyperthymia and lower dysthymia (H-H group). Limitations: The small sample size did not allow the generalization of the present findings. Conclusions: Differences among temperament groups measured by the TEMPS-A are associated with differences in their MRIs, indicating that different temperament profiles are associated with differences in the subcortical structures of the brain. The implications of the results were discussed.

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