Affektív és kognitív döntéshozatali funkciók major depresszióban: a prefrontális cortex, a szerotonintranszporter és a személyiség szerepe.

Translated title of the contribution: Affective and cognitive decision making in major depression: influence of the prefrontal cortex, serotonin transporter genotype and personality traits

Anita Must, Szatmár Horváth, Zoltán Janka

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Patients with major depressive disorder (MDD) show neuropsychological impairments, including deficient executive functions and suboptimal decision-making strategies, which are mediated by several brain regions. In the development of these symptoms the pathology of the prefrontal cortex (PFC), including the dorsolateral, ventromedial and orbitofrontal regions, may also play an important role. Neuropsychological assessment is a useful tool in detecting and measuring these deficiencies, showing that patients with MDD exhibit altered sensitivity to reward and punishment. However, impairment of emotional decision-making strategies in MDD is influenced by genetic variations (5-HTTLPR polymorphism) and personality traits, which seem to have a higher predictive value on decision making performance than the clinical symptoms.

Translated title of the contributionAffective and cognitive decision making in major depression: influence of the prefrontal cortex, serotonin transporter genotype and personality traits
Original languageHungarian
Pages (from-to)175-179
Number of pages5
JournalIdeggyógyászati szemle
Volume61
Issue number5-6
Publication statusPublished - May 30 2008

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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