Aetiological studies of hypospadias in Hungary

E. Czeizel, J. Toth, E. Erodi

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

A complex aetiological (epidemiological, teratological and genetic) study was made in 294 index patients with simple isolated hypospadias. The epidemiological study conducted by the help of personal interviews of the mothers revealed a higher frequency of index patients among children born between August and December, among twins, mainly monozygotic, and finally in the lower birth weight groups and among first-borns. The teratological study showed a higher frequency in mothers of index patients who had had sex hormone treatment, mainly progestogen, before the 16th gestational week. This seems to indicate the aetiological role of fetal androgen deficit caused by the regulation disturbances of human choriogonadotropin. The genetic family study completed by personal examination of first-degree male relatives showed a familial clustering (4.0% versus a point prevalence of 0.44% in live-births). Both the pattern of affected relatives (h2 values 0.62 ± 0.21 and 0.72 ± 0.33 in father and brothers, respectively, not differing significantly from each other) and further characteristics (other malformations were not frequent in relatives) correspond to the multifactorial-threshold model.

Original languageEnglish
Pages (from-to)166-171
Number of pages6
JournalHuman Heredity
Volume29
Issue number3
Publication statusPublished - 1979

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Hypospadias
Hungary
Mothers
Monozygotic Twins
Live Birth
Gonadal Steroid Hormones
Progestins
Chorionic Gonadotropin
Birth Weight
Fathers
Androgens
Cluster Analysis
Siblings
Epidemiologic Studies
Interviews
Therapeutics

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Czeizel, E., Toth, J., & Erodi, E. (1979). Aetiological studies of hypospadias in Hungary. Human Heredity, 29(3), 166-171.

Aetiological studies of hypospadias in Hungary. / Czeizel, E.; Toth, J.; Erodi, E.

In: Human Heredity, Vol. 29, No. 3, 1979, p. 166-171.

Research output: Contribution to journalArticle

Czeizel, E, Toth, J & Erodi, E 1979, 'Aetiological studies of hypospadias in Hungary', Human Heredity, vol. 29, no. 3, pp. 166-171.
Czeizel, E. ; Toth, J. ; Erodi, E. / Aetiological studies of hypospadias in Hungary. In: Human Heredity. 1979 ; Vol. 29, No. 3. pp. 166-171.
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