ADVERSE EFFECTS OF ENVIRONMENTAL CHEMICALS AND PSYCHOTROPIC DRUGS. QUANTITATIVE INTERPRETATION OF FUNCTIONAL TESTS: the use of 'reference substances'

Research output: Chapter in Book/Report/Conference proceedingChapter

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Abstract

Methods for detecting the early detrimental effects of pesticides on the nervous system are reported. Rats were dosed with small quantities of the agents. The methods comprise electrophysiological and behavioural tests (resting EEGs, EEG examinations during light and sound stimulation, maze learning, Pavlov's conditioned reflexes, Skinner box tests, orientation activity test) that were adapted to subacute toxicological examinations in order to obtain quantitative data. Reference substances (amphetamine and chlorpromazine) were also applied in the experiments for the sake of better quantitative evaluation and in order to compare the effects of unknown pesticides to the well known action of other substances. After a survey of methods, some selected details and results of the experiments with the reference substances and pesticides are reported. Based on findings the following has been concluded: Functional electrophysiological and behavioural tests are more sensitive than the determination of the cholinesterase activity in blood and brain; for every substance to be tested it is indispensable to carry out several kinds of electrophysiological and behavioural examinations and only after having compared all results can a final conclusion be drawn; toxicity limit should be the lowest concentration giving a positive result in various tests; in modern toxicological studies, special importance is attached to EEG examinations and records should be processed by computer analysis in digital form; reference substances are of particular aid in the quantitative evaluation of results; and the comparison with different reference substances must be made separately one by one for every test and for every substance because one and the same pesticide may resemble various reference substances in the different tests.

Original languageEnglish
Title of host publicationELSEVIER SCI.PUBL.CO.
Pages125-140
Number of pages16
VolumeVol 1
Publication statusPublished - 1973

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Psychotropic Drugs
Pesticides
Electroencephalography
Toxicology
Maze Learning
Classical Conditioning
Cholinesterases
Chlorpromazine
Amphetamine
Nervous System
Light
Brain
Behavior Rating Scale

ASJC Scopus subject areas

  • Medicine(all)

Cite this

ADVERSE EFFECTS OF ENVIRONMENTAL CHEMICALS AND PSYCHOTROPIC DRUGS. QUANTITATIVE INTERPRETATION OF FUNCTIONAL TESTS : the use of 'reference substances'. / Dési, I.

ELSEVIER SCI.PUBL.CO.. Vol. Vol 1 1973. p. 125-140.

Research output: Chapter in Book/Report/Conference proceedingChapter

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