Adverse effects of danazol prophylaxis on the lipid profiles of patients with hereditary angioedema

G. Széplaki, L. Varga, Szilvia Valentin, Mónika Kleiber, I. Karádi, László Romics, G. Füst, H. Farkas

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Background: Hereditary angioedema (HAE) is a rare disorder caused by the deficiency of the C1-inhibitor gene (C1INH). Patients experience recurrent bouts of edema, which can occur in almost any region of the body. As regards the treatment of the disease, danazol (an attenuated androgen) is used, among other agents, for long-term prophylaxis. Objective: The aim of this study was to investigate the possible adverse effects of danazol on serum lipid profile, as well as to ascertain whether danazol treatment is associated with an increased risk of atherosclerosis. Methods: Serum concentrations of total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, apolipoprotein A-I, apolipoprotein B-100, and lipoprotein(a) were compared between danazol-treated patients with HAE and 2 control groups (ie, patients who did not receive long-term danazol prophylaxis and untreated healthy subjects). Results: Serum concentrations of HDL (P = .0002 and P

Original languageEnglish
Pages (from-to)864-869
Number of pages6
JournalJournal of Allergy and Clinical Immunology
Volume115
Issue number4
DOIs
Publication statusPublished - Apr 2005

Fingerprint

Hereditary Angioedemas
Danazol
Lipids
Serum
Apolipoprotein B-100
Body Regions
Lipoprotein(a)
Apolipoprotein A-I
HDL Lipoproteins
HDL Cholesterol
Androgens
Edema
Atherosclerosis
Healthy Volunteers
Control Groups
Therapeutics
Genes

Keywords

  • Adverse effects
  • Atherosclerosis
  • Danazol
  • Hereditary angioedema
  • High-density lipoprotein
  • Lipids
  • Low-density lipoprotein

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Adverse effects of danazol prophylaxis on the lipid profiles of patients with hereditary angioedema. / Széplaki, G.; Varga, L.; Valentin, Szilvia; Kleiber, Mónika; Karádi, I.; Romics, László; Füst, G.; Farkas, H.

In: Journal of Allergy and Clinical Immunology, Vol. 115, No. 4, 04.2005, p. 864-869.

Research output: Contribution to journalArticle

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AU - Valentin, Szilvia

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AU - Karádi, I.

AU - Romics, László

AU - Füst, G.

AU - Farkas, H.

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