Advantages of structural similarities of the reactants in optical resolution processes

Research output: Chapter in Book/Report/Conference proceedingChapter

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Abstract

Advantages and limitations of the use of structurally similar compounds in racemate resolution via diastereoisomeric salt formation are discussed in this review. An effective conception on "derivative resolving agents" (use of the optically active derivatives of a racemate as resolving agents) is presented by examples and the method is extended to the homologous series of the derivative resolving agents and/or achiral additives. A recently developed distillation version of the family approach to optical resolution and the novel, solvent-free resolution methods using a half equivalent amount of resolving agent are also discussed.

Original languageEnglish
Title of host publicationNovel Optical Resolution Technologies
EditorsKenichi Sakai, Rui Tamura, Noriaki Hirayama, Vincenzo Balzani, Armin Meijere, Kendall Houk, Horst Kessler, Jean-Marie Lehn, Steven Ley, Stuart Schreiber, Joachim Thiem, Barry Trost, F. Voegtle, Hisashi Yamamoto
Pages133-157
Number of pages25
DOIs
Publication statusPublished - Aug 30 2006

Publication series

NameTopics in Current Chemistry
Volume269
ISSN (Print)0340-1022

Keywords

  • Derivative resolving agent
  • Diastereoisomeric salt
  • Homo- and heterochiral assemblies
  • Optical resolution
  • Structural similarity

ASJC Scopus subject areas

  • Chemistry(all)

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    Faigl, F., Schindler, J., & Fogassy, E. (2006). Advantages of structural similarities of the reactants in optical resolution processes. In K. Sakai, R. Tamura, N. Hirayama, V. Balzani, A. Meijere, K. Houk, H. Kessler, J-M. Lehn, S. Ley, S. Schreiber, J. Thiem, B. Trost, F. Voegtle, & H. Yamamoto (Eds.), Novel Optical Resolution Technologies (pp. 133-157). (Topics in Current Chemistry; Vol. 269). https://doi.org/10.1007/128_2006_076