Advantages of cross-linked versus linear hyaluronic acid for semisolid skin delivery systems

Szilvia Berkó, Mónika Maroda, Magdolna Bodnár, Gábor Eros, Petra Hartmann, Kinga Szentner, P. Szabó-Révész, L. Kemény, J. Borbély, Erzsébet Csányi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Cross-linking of the hyaluronic acid (hyaluronan, HA) molecule may be a possible chemical modification via which to improve the problem of the penetration of HA. The successful preparation and characterization of stable nanoparticulate systems based on HA were described and discussed previously. The purpose of the present study is to compare hydrogels based on linear or cross-linked HA as potential semisolid drug delivery forms from the aspects of deep HA penetration through the skin. The rheological properties, hydration, irritation effect, in vitro and in vivo skin penetration were studied. The hydration effect was kept and the rheological parameters were slightly changed after the cross-linking procedure. Diffusion and penetration studies demonstrated that the formation of smaller particles of HA by means of cross-linking resulted in better diffusion through a synthetic membrane and better penetration through the human epidermis and living animal skin as compared with linear HA, which did not penetrate.

Original languageEnglish
Pages (from-to)2511-2517
Number of pages7
JournalEuropean Polymer Journal
Volume49
Issue number9
DOIs
Publication statusPublished - Sep 2013

Fingerprint

semisolids
Hyaluronic acid
Hyaluronic Acid
delivery
Skin
penetration
Hydration
acids
Chemical modification
hydration
Drug delivery
Hydrogels
irritation
Animals
epidermis
Membranes
Molecules
animals
drugs
membranes

Keywords

  • Cross-linking
  • Hyaluronic acid
  • Skin hydration
  • Skin penetration

ASJC Scopus subject areas

  • Polymers and Plastics
  • Physics and Astronomy(all)
  • Organic Chemistry

Cite this

Advantages of cross-linked versus linear hyaluronic acid for semisolid skin delivery systems. / Berkó, Szilvia; Maroda, Mónika; Bodnár, Magdolna; Eros, Gábor; Hartmann, Petra; Szentner, Kinga; Szabó-Révész, P.; Kemény, L.; Borbély, J.; Csányi, Erzsébet.

In: European Polymer Journal, Vol. 49, No. 9, 09.2013, p. 2511-2517.

Research output: Contribution to journalArticle

Berkó, Szilvia ; Maroda, Mónika ; Bodnár, Magdolna ; Eros, Gábor ; Hartmann, Petra ; Szentner, Kinga ; Szabó-Révész, P. ; Kemény, L. ; Borbély, J. ; Csányi, Erzsébet. / Advantages of cross-linked versus linear hyaluronic acid for semisolid skin delivery systems. In: European Polymer Journal. 2013 ; Vol. 49, No. 9. pp. 2511-2517.
@article{238b66325f55457880e8d51b76f9c4fa,
title = "Advantages of cross-linked versus linear hyaluronic acid for semisolid skin delivery systems",
abstract = "Cross-linking of the hyaluronic acid (hyaluronan, HA) molecule may be a possible chemical modification via which to improve the problem of the penetration of HA. The successful preparation and characterization of stable nanoparticulate systems based on HA were described and discussed previously. The purpose of the present study is to compare hydrogels based on linear or cross-linked HA as potential semisolid drug delivery forms from the aspects of deep HA penetration through the skin. The rheological properties, hydration, irritation effect, in vitro and in vivo skin penetration were studied. The hydration effect was kept and the rheological parameters were slightly changed after the cross-linking procedure. Diffusion and penetration studies demonstrated that the formation of smaller particles of HA by means of cross-linking resulted in better diffusion through a synthetic membrane and better penetration through the human epidermis and living animal skin as compared with linear HA, which did not penetrate.",
keywords = "Cross-linking, Hyaluronic acid, Skin hydration, Skin penetration",
author = "Szilvia Berk{\'o} and M{\'o}nika Maroda and Magdolna Bodn{\'a}r and G{\'a}bor Eros and Petra Hartmann and Kinga Szentner and P. Szab{\'o}-R{\'e}v{\'e}sz and L. Kem{\'e}ny and J. Borb{\'e}ly and Erzs{\'e}bet Cs{\'a}nyi",
year = "2013",
month = "9",
doi = "10.1016/j.eurpolymj.2013.04.001",
language = "English",
volume = "49",
pages = "2511--2517",
journal = "European Polymer Journal",
issn = "0014-3057",
publisher = "Elsevier Limited",
number = "9",

}

TY - JOUR

T1 - Advantages of cross-linked versus linear hyaluronic acid for semisolid skin delivery systems

AU - Berkó, Szilvia

AU - Maroda, Mónika

AU - Bodnár, Magdolna

AU - Eros, Gábor

AU - Hartmann, Petra

AU - Szentner, Kinga

AU - Szabó-Révész, P.

AU - Kemény, L.

AU - Borbély, J.

AU - Csányi, Erzsébet

PY - 2013/9

Y1 - 2013/9

N2 - Cross-linking of the hyaluronic acid (hyaluronan, HA) molecule may be a possible chemical modification via which to improve the problem of the penetration of HA. The successful preparation and characterization of stable nanoparticulate systems based on HA were described and discussed previously. The purpose of the present study is to compare hydrogels based on linear or cross-linked HA as potential semisolid drug delivery forms from the aspects of deep HA penetration through the skin. The rheological properties, hydration, irritation effect, in vitro and in vivo skin penetration were studied. The hydration effect was kept and the rheological parameters were slightly changed after the cross-linking procedure. Diffusion and penetration studies demonstrated that the formation of smaller particles of HA by means of cross-linking resulted in better diffusion through a synthetic membrane and better penetration through the human epidermis and living animal skin as compared with linear HA, which did not penetrate.

AB - Cross-linking of the hyaluronic acid (hyaluronan, HA) molecule may be a possible chemical modification via which to improve the problem of the penetration of HA. The successful preparation and characterization of stable nanoparticulate systems based on HA were described and discussed previously. The purpose of the present study is to compare hydrogels based on linear or cross-linked HA as potential semisolid drug delivery forms from the aspects of deep HA penetration through the skin. The rheological properties, hydration, irritation effect, in vitro and in vivo skin penetration were studied. The hydration effect was kept and the rheological parameters were slightly changed after the cross-linking procedure. Diffusion and penetration studies demonstrated that the formation of smaller particles of HA by means of cross-linking resulted in better diffusion through a synthetic membrane and better penetration through the human epidermis and living animal skin as compared with linear HA, which did not penetrate.

KW - Cross-linking

KW - Hyaluronic acid

KW - Skin hydration

KW - Skin penetration

UR - http://www.scopus.com/inward/record.url?scp=84881370550&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881370550&partnerID=8YFLogxK

U2 - 10.1016/j.eurpolymj.2013.04.001

DO - 10.1016/j.eurpolymj.2013.04.001

M3 - Article

VL - 49

SP - 2511

EP - 2517

JO - European Polymer Journal

JF - European Polymer Journal

SN - 0014-3057

IS - 9

ER -