Advances in Na+/I- symporter (NIS) research in the thyroid and beyond

O. Dohán, Nancy Carrasco

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

The Na+/I- symporter (NIS) is a plasma membrane glycoprotein that mediates active iodide uptake in the thyroid - the essential first step in thyroid hormone biosynthesis - and in other tissues, such as salivary and lactating mammary glands. Thyroidal radioiodide uptake has been used for over 60 years in the diagnosis and effective treatment of thyroid cancer and other diseases. However, the NIS cDNA was only isolated in 1996 by expression cloning in Xenopus laevis oocytes, marking the beginning of the molecular characterization of NIS and the study of its regulation, both in the thyroid and other tissues. One of the most exciting current areas of NIS research - radioiodide treatment of extrathyroidal cancers - was launched by the discovery of functional expression of endogenous NIS in breast cancer and by the ectopic transfer of the NIS gene into otherwise non NIS-expressing cancers. This review summarizes the main findings in NIS research, emphasizing the most recent developments.

Original languageEnglish
Pages (from-to)59-70
Number of pages12
JournalMolecular and Cellular Endocrinology
Volume213
Issue number1
DOIs
Publication statusPublished - Dec 31 2003

Fingerprint

Symporters
Thyroid Gland
Research
Tissue
Cloning
Biosynthesis
Membrane Glycoproteins
Xenopus laevis
Iodides
Cell membranes
Human Mammary Glands
Thyroid Hormones
Thyroid Neoplasms
Oocytes
Organism Cloning
Neoplasms
Complementary DNA
Genes
Cell Membrane
Breast Neoplasms

Keywords

  • Cancer
  • Iodide transport
  • Membrane proteins
  • Sodium/iodide symporter (NIS)
  • Subcellular localization
  • Targeted radiotherapy

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Advances in Na+/I- symporter (NIS) research in the thyroid and beyond. / Dohán, O.; Carrasco, Nancy.

In: Molecular and Cellular Endocrinology, Vol. 213, No. 1, 31.12.2003, p. 59-70.

Research output: Contribution to journalArticle

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