Advances in glycogen phosphorylase inhibitor design

N. G. Oikonomakos, L. Somsák

Research output: Contribution to journalReview article

81 Citations (Scopus)

Abstract

The regulation of glycogen metabolism is a major therapeutic strategy for blood glucose control in type 2 diabetes. Because glycogen phosphorylase catalyzes the first step in the phosphorolysis of glycogen, it has become a potential key target for controlling hyperglycemia in this disease. This review focuses on advances in new, mostly synthetic, molecules that inhibit glycogen phosphorylase, and describes progress in our understanding of the mechanism of action of these inhibitors gained through X-ray crystallographic studies.

Original languageEnglish
Pages (from-to)379-395
Number of pages17
JournalCurrent Opinion in Investigational Drugs
Volume9
Issue number4
Publication statusPublished - Apr 1 2008

Keywords

  • Antihyperglycemics
  • Drug design
  • Enzyme binding site
  • Glycogen phosphorylase inhibitor
  • Hyperglycemia
  • SAR
  • Type 2 diabetes
  • X-ray crystallography

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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