Advanced methods for the synthesis of 3-substituted 1H-isoindol-1-ones

Génes Stájer, Ferenc Csende

Research output: Contribution to journalReview article

31 Citations (Scopus)


Both direct and multistep reactions, involving the application of carbonyl compounds, e. g. oxoacids, phthalimides, 2-iodobenzamides or acylhatides, have been developed as novel synthetic routes for the preparation of 3-substituted 2,3-dihydro-1H-isoindol-1-ones, which are reviewed here. Alternatively, reductive or acid-catalyzed rearrangements of certain heterocycles lead to the formation of 3-substituted isoindolones. Asymmetric syntheses too have been described.

Original languageEnglish
Pages (from-to)1277-1286
Number of pages10
JournalCurrent Organic Chemistry
Issue number13
Publication statusPublished - Sep 1 2005

ASJC Scopus subject areas

  • Organic Chemistry

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