Adrenomedullin gene expression in the rat heart is stimulated by acute pressure overload: Blunted effect in experimental hypertension

Hannu Romppanen, Minna Marttila, Jarkko Magga, Olli Vuolteenaho, Pietari Kinnunen, I. Szokodi, Heikki Ruskoaho

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The levels of adrenomedullin (ADM), a newly discovered vasodilating and natriuretic peptide, are elevated in plasma and ventricular myocardium in human congestive heart failure suggesting that cardiac synthesis may contribute to the plasma concentrations of ADM. To examine the time course of induction and mechanisms regulating cardiac ADM gene expression, we determined the effect of acute and short-term cardiac overload on ventricular ADM mRNA and immunoreactive ADM (ir-ADM) levels in conscious rats. Acute pressure overload was produced by infusion of arginine-vasopressin (AVP, 0.05 μg/kg/min, iv) for 2 h into 12-week-old hypertensive TGR (mREN-2)27 rats and normotensive Sprague-Dawley (SD) rats. Hypertension and marked left ventricular hypertrophy were associated with 2,2-times higher ir-ADM levels in the left ventricular epicardial layer (178 ± 36 vs. 81 ± 23 fmol/g, P

Original languageEnglish
Pages (from-to)2636-2639
Number of pages4
JournalEndocrinology
Volume138
Issue number6
DOIs
Publication statusPublished - 1997

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Adrenomedullin
Hypertension
Gene Expression
Pressure
Natriuretic Peptides
Arginine Vasopressin
Left Ventricular Hypertrophy
Sprague Dawley Rats
Myocardium
Heart Failure
Messenger RNA

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Adrenomedullin gene expression in the rat heart is stimulated by acute pressure overload : Blunted effect in experimental hypertension. / Romppanen, Hannu; Marttila, Minna; Magga, Jarkko; Vuolteenaho, Olli; Kinnunen, Pietari; Szokodi, I.; Ruskoaho, Heikki.

In: Endocrinology, Vol. 138, No. 6, 1997, p. 2636-2639.

Research output: Contribution to journalArticle

Romppanen, Hannu ; Marttila, Minna ; Magga, Jarkko ; Vuolteenaho, Olli ; Kinnunen, Pietari ; Szokodi, I. ; Ruskoaho, Heikki. / Adrenomedullin gene expression in the rat heart is stimulated by acute pressure overload : Blunted effect in experimental hypertension. In: Endocrinology. 1997 ; Vol. 138, No. 6. pp. 2636-2639.
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