An inverse correlation was found between the number of pulses and sympathetic blockade by PGE1 (10-8 g/ml) in the isolated field stimulated guineapig vas deferens. The higher the number of pulses applied at a given frequency the smaller was the inhibition by PGE1 of neuroeffector transmission. At 100 shocks using 10 Hz stimulation, PGE1 no longer decreased the height of twitches of the vas deferens; the velocity of contractions was, however, decreased. Sympathetic transmission in the rabbit jejunum was blocked by a somewhat higher dose of PGE1 (3x10-8 g/ml). In this organ an increase in pulse number produced no detectable change in PGE1 induced blockade. PGE1 (10-8 g/ml) did not influence the shock number effect curve of the cat nictitating membrane and did not modify noradrenaline induced contractions. In longitudinal muscle strips of guineapig ileum PGE1 (2x10-8 g/ml) potentiated the effects of stimulation and of acetylcholine without causing at the same time a rise in tone. As acetylcholine release was not influenced, a prejunctional effect can be excluded.
|Number of pages||10|
|Journal||Polish journal of pharmacology and pharmacy|
|Publication status||Published - Jan 1 1974|
ASJC Scopus subject areas
- Pharmaceutical Science