Adrenalectomy aggravates ischemic brain edema in female Sprague-Dawley rats with carotid arteries ligated

Cs Ábrahám, M. Koltai, Tósaki, Cs Ábrahám, F. Joó, P. Szerdahelyi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The effect of adrenalectomy has been investigated in a model of global cerebral ischemia. After bilateral carotid ligation the mortality rate was increased in adrenalectomized rats, and this effect was prevented by glucocorticoid pre-treatment. Adrenalectomy accelerated the appearance of the symptoms of cerebral ischemia, resulting in a moderate aggravation of brain edema and in a significant decrease in the concentration of high-energy phosphate esters. Our findings support the view that endogenous glucocorticoids may play a role in the amelioration of ischemic brain injuries in rats.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalProgress in Brain Research
Volume91
Issue numberC
DOIs
Publication statusPublished - Jan 1 1992

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Adrenalectomy aggravates ischemic brain edema in female Sprague-Dawley rats with carotid arteries ligated'. Together they form a unique fingerprint.

  • Cite this