Adrenal cortex - A newly recognized peripheral site of action of enkephalins

K. Rácz, E. Gláz, R. Kiss, Gy Lada, I. Varga, S. Vida, K. Di Gleria, K. Medzihradszky, K. Lichtwald, P. Vecsei

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Two naturally occuring enkephalins, Leu- and Met-enkephalin, were shown to inhibit adrenal corticosteroid biosynthesis. In isolated rat adrenal cell system corticosterone, desoxycorticosterone and aldosterone, and in isolated bovine adrenal cells cortisol, corticosterone and aldosterone production were markedly depressed in a dose-dependent fashion, both under basal conditions and following stimulation with ACTH1-24. The inhibitory action of enkephalins on corticosteroid synthesis could be augmented by increasing the Ca2+-concentration in the cell-containing medium. The demonstration that opioid peptides interfere with corticosteroidogenesis directly at the adrenal level points to the existence of a peripheral neuroendocrine relationship.

Original languageEnglish
Pages (from-to)1346-1353
Number of pages8
JournalBiochemical and biophysical research communications
Volume97
Issue number4
DOIs
Publication statusPublished - Dec 31 1980

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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