Adjuvant Quil A improves protection in mice and enhances opsonic capacity of antisera induced by pneumococcal polysaccharide conjugate vaccines

E. Alonso De Velasco, H. A.Th Dekker, P. Antal, K. P. Jalink, J. A.G. van Strijp, A. F.M. Verheul, J. Verhoef, H. Snippe

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Abstract

The adjuvant effect of Quil A on the primary antibody response of mice to pneumococcal capsular polysaccharide conjugates was examined. Quil A increased the anti-capsular polysaccharide antibody titres, the protection against Streptococcus pneumoniae, and the opsonic capacity of the antibodies as measured in a newly developed in vitro phagocytosis assay, using the mouse macrophage cell line J774.

Original languageEnglish
Pages (from-to)1419-1422
Number of pages4
JournalVaccine
Volume12
Issue number15
DOIs
Publication statusPublished - 1994

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Keywords

  • Quil A
  • Streptococcus pneumoniae
  • opsonization

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Alonso De Velasco, E., Dekker, H. A. T., Antal, P., Jalink, K. P., van Strijp, J. A. G., Verheul, A. F. M., Verhoef, J., & Snippe, H. (1994). Adjuvant Quil A improves protection in mice and enhances opsonic capacity of antisera induced by pneumococcal polysaccharide conjugate vaccines. Vaccine, 12(15), 1419-1422. https://doi.org/10.1016/0264-410X(94)90151-1