Adiposity, Obesity, and Arterial Aging: Longitudinal Study of Aortic Stiffness in the Whitehall II Cohort

Eric J. Brunner, Martin J. Shipley, Sara Ahmadi-Abhari, A. Tabák, Carmel M. Mceniery, Ian B. Wilkinson, Michael G. Marmot, Archana Singh-Manoux, Mika Kivimaki

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We sought to determine whether adiposity in later midlife is an independent predictor of accelerated stiffening of the aorta. Whitehall II study participants (3789 men; 1383 women) underwent carotid-femoral applanation tonometry at the mean age of 66 and again 4 years later. General adiposity by body mass index, central adiposity by waist circumference and waist:hip ratio, and fat mass percent by body impedance were assessed 5 years before and at baseline. In linear mixed models adjusted for age, sex, ethnicity, and mean arterial pressure, all adiposity measures were associated with aortic stiffening measured as increase in pulse wave velocity (PWV) between baseline and follow-up. The associations were similar in the metabolically healthy and unhealthy, according to Adult Treatment Panel-III criteria excluding waist circumference. C-reactive protein and interleukin-6 levels accounted for part of the longitudinal association between adiposity and PWV change. Adjusting for chronic disease, antihypertensive medication and risk factors, standardized effects of general and central adiposity and fat mass percent on PWV increase (m/s) were similar (0.14, 95 confidence interval: 0.05-0.24, P=0.003; 0.17, 0.08-0.27, P

Original languageEnglish
Pages (from-to)294-300
Number of pages7
JournalHypertension
Volume66
Issue number2
DOIs
Publication statusPublished - Aug 20 2015

Fingerprint

Vascular Stiffness
Adiposity
Longitudinal Studies
Obesity
Pulse Wave Analysis
Waist Circumference
Fats
Waist-Hip Ratio
Manometry
Thigh
Electric Impedance
C-Reactive Protein
Antihypertensive Agents
Aorta
Linear Models
Interleukin-6
Arterial Pressure
Body Mass Index
Chronic Disease
Confidence Intervals

Keywords

  • Aging
  • Arterial stiffness
  • Epidemiology
  • Longitudinal studies
  • Obesity

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Brunner, E. J., Shipley, M. J., Ahmadi-Abhari, S., Tabák, A., Mceniery, C. M., Wilkinson, I. B., ... Kivimaki, M. (2015). Adiposity, Obesity, and Arterial Aging: Longitudinal Study of Aortic Stiffness in the Whitehall II Cohort. Hypertension, 66(2), 294-300. https://doi.org/10.1161/HYPERTENSIONAHA.115.05494

Adiposity, Obesity, and Arterial Aging : Longitudinal Study of Aortic Stiffness in the Whitehall II Cohort. / Brunner, Eric J.; Shipley, Martin J.; Ahmadi-Abhari, Sara; Tabák, A.; Mceniery, Carmel M.; Wilkinson, Ian B.; Marmot, Michael G.; Singh-Manoux, Archana; Kivimaki, Mika.

In: Hypertension, Vol. 66, No. 2, 20.08.2015, p. 294-300.

Research output: Contribution to journalArticle

Brunner, EJ, Shipley, MJ, Ahmadi-Abhari, S, Tabák, A, Mceniery, CM, Wilkinson, IB, Marmot, MG, Singh-Manoux, A & Kivimaki, M 2015, 'Adiposity, Obesity, and Arterial Aging: Longitudinal Study of Aortic Stiffness in the Whitehall II Cohort', Hypertension, vol. 66, no. 2, pp. 294-300. https://doi.org/10.1161/HYPERTENSIONAHA.115.05494
Brunner, Eric J. ; Shipley, Martin J. ; Ahmadi-Abhari, Sara ; Tabák, A. ; Mceniery, Carmel M. ; Wilkinson, Ian B. ; Marmot, Michael G. ; Singh-Manoux, Archana ; Kivimaki, Mika. / Adiposity, Obesity, and Arterial Aging : Longitudinal Study of Aortic Stiffness in the Whitehall II Cohort. In: Hypertension. 2015 ; Vol. 66, No. 2. pp. 294-300.
@article{10cbfef3d8f440d3bd6c827a42715135,
title = "Adiposity, Obesity, and Arterial Aging: Longitudinal Study of Aortic Stiffness in the Whitehall II Cohort",
abstract = "We sought to determine whether adiposity in later midlife is an independent predictor of accelerated stiffening of the aorta. Whitehall II study participants (3789 men; 1383 women) underwent carotid-femoral applanation tonometry at the mean age of 66 and again 4 years later. General adiposity by body mass index, central adiposity by waist circumference and waist:hip ratio, and fat mass percent by body impedance were assessed 5 years before and at baseline. In linear mixed models adjusted for age, sex, ethnicity, and mean arterial pressure, all adiposity measures were associated with aortic stiffening measured as increase in pulse wave velocity (PWV) between baseline and follow-up. The associations were similar in the metabolically healthy and unhealthy, according to Adult Treatment Panel-III criteria excluding waist circumference. C-reactive protein and interleukin-6 levels accounted for part of the longitudinal association between adiposity and PWV change. Adjusting for chronic disease, antihypertensive medication and risk factors, standardized effects of general and central adiposity and fat mass percent on PWV increase (m/s) were similar (0.14, 95 confidence interval: 0.05-0.24, P=0.003; 0.17, 0.08-0.27, P",
keywords = "Aging, Arterial stiffness, Epidemiology, Longitudinal studies, Obesity",
author = "Brunner, {Eric J.} and Shipley, {Martin J.} and Sara Ahmadi-Abhari and A. Tab{\'a}k and Mceniery, {Carmel M.} and Wilkinson, {Ian B.} and Marmot, {Michael G.} and Archana Singh-Manoux and Mika Kivimaki",
year = "2015",
month = "8",
day = "20",
doi = "10.1161/HYPERTENSIONAHA.115.05494",
language = "English",
volume = "66",
pages = "294--300",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Adiposity, Obesity, and Arterial Aging

T2 - Longitudinal Study of Aortic Stiffness in the Whitehall II Cohort

AU - Brunner, Eric J.

AU - Shipley, Martin J.

AU - Ahmadi-Abhari, Sara

AU - Tabák, A.

AU - Mceniery, Carmel M.

AU - Wilkinson, Ian B.

AU - Marmot, Michael G.

AU - Singh-Manoux, Archana

AU - Kivimaki, Mika

PY - 2015/8/20

Y1 - 2015/8/20

N2 - We sought to determine whether adiposity in later midlife is an independent predictor of accelerated stiffening of the aorta. Whitehall II study participants (3789 men; 1383 women) underwent carotid-femoral applanation tonometry at the mean age of 66 and again 4 years later. General adiposity by body mass index, central adiposity by waist circumference and waist:hip ratio, and fat mass percent by body impedance were assessed 5 years before and at baseline. In linear mixed models adjusted for age, sex, ethnicity, and mean arterial pressure, all adiposity measures were associated with aortic stiffening measured as increase in pulse wave velocity (PWV) between baseline and follow-up. The associations were similar in the metabolically healthy and unhealthy, according to Adult Treatment Panel-III criteria excluding waist circumference. C-reactive protein and interleukin-6 levels accounted for part of the longitudinal association between adiposity and PWV change. Adjusting for chronic disease, antihypertensive medication and risk factors, standardized effects of general and central adiposity and fat mass percent on PWV increase (m/s) were similar (0.14, 95 confidence interval: 0.05-0.24, P=0.003; 0.17, 0.08-0.27, P

AB - We sought to determine whether adiposity in later midlife is an independent predictor of accelerated stiffening of the aorta. Whitehall II study participants (3789 men; 1383 women) underwent carotid-femoral applanation tonometry at the mean age of 66 and again 4 years later. General adiposity by body mass index, central adiposity by waist circumference and waist:hip ratio, and fat mass percent by body impedance were assessed 5 years before and at baseline. In linear mixed models adjusted for age, sex, ethnicity, and mean arterial pressure, all adiposity measures were associated with aortic stiffening measured as increase in pulse wave velocity (PWV) between baseline and follow-up. The associations were similar in the metabolically healthy and unhealthy, according to Adult Treatment Panel-III criteria excluding waist circumference. C-reactive protein and interleukin-6 levels accounted for part of the longitudinal association between adiposity and PWV change. Adjusting for chronic disease, antihypertensive medication and risk factors, standardized effects of general and central adiposity and fat mass percent on PWV increase (m/s) were similar (0.14, 95 confidence interval: 0.05-0.24, P=0.003; 0.17, 0.08-0.27, P

KW - Aging

KW - Arterial stiffness

KW - Epidemiology

KW - Longitudinal studies

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84937556396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84937556396&partnerID=8YFLogxK

U2 - 10.1161/HYPERTENSIONAHA.115.05494

DO - 10.1161/HYPERTENSIONAHA.115.05494

M3 - Article

C2 - 26056335

AN - SCOPUS:84937556396

VL - 66

SP - 294

EP - 300

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 2

ER -