Adiponectin trajectories before type 2 diabetes diagnosis: Whitehall II study

Adam G. Tabák, Maren Carstensen, Daniel R. Witte, Eric J. Brunner, Martin J. Shipley, Markus Jokela, Michael Roden, Mika Kivimäki, Christian Herder

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OBJECTIVE-The role of adiponectin in the natural history of diabetes is not well characterized. We set out to characterize prediagnosis trajectories of adiponectin in individuals who develop type 2 diabetes. RESEARCH DESIGN AND METHODS-In a case-cohort study (335 incident diabetes case and 2,474 noncase subjects) nested in the Whitehall II study, serum adiponectin was measured up to three times per participant (1991-1993, 1997-1999, and 2003-2004). Multilevel models adjusted for age and ethnicity were fitted to assess 13-year trajectories of log-transformed adiponectin preceding diabetes diagnosis or a randomly selected time point during follow-up (year0) based on 755/5,095 (case/noncase) person-examinations. RESULTS-Adiponectin levels were lower in diabetes case than in noncase subjects (median 7,141 [interquartile range 5,187-10,304] vs. 8,818 [6,535-12,369] ng/mL at baseline, P < 0.0001). Control subjects showed a modest decline in adiponectin throughout follow-up (0.3%per year, P<0.0001) at higher levels inwomen than inmen (difference at year0: 5,358ng/mL, P<0.0001). Female case and early-onset case (age at diagnosis <52 years) subjects had a steeper decline than control subjects (slope differenc-21.1% per year, P = 0.001 in females -21.6% per year in early-onset case subjects, P = 0.034). In men, adiponectin slopes for case and noncase subjects were parallel. The slope differences by diabetes onset were largely attenuated after adjustment for changes in obesity, whereas the sex-specific slope differences were independent of obesity. CONCLUSIONS-Lower adiponectin levels were observed already a decade before the diagnosis of diabetes. The marked sex difference in trajectories suggests that sex-specific mechanisms affect the association between adiponectin levels and diabetes development.

Original languageEnglish
Pages (from-to)2540-2547
Number of pages8
JournalDiabetes care
Issue number12
Publication statusPublished - Dec 2012

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialised Nursing

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    Tabák, A. G., Carstensen, M., Witte, D. R., Brunner, E. J., Shipley, M. J., Jokela, M., Roden, M., Kivimäki, M., & Herder, C. (2012). Adiponectin trajectories before type 2 diabetes diagnosis: Whitehall II study. Diabetes care, 35(12), 2540-2547.