The effects of the alpha-melanocyte-stimulating hormone (α-MSH) (10-7-10-5 M) and the β-adrenoceptor agonist isoprenaline (10-9-10-4 M) on adenylate cyclase (AC) activity were investigated in homogenates of the human IGR 1 melanoma cells with or without additional GTP. Basal AC activity was increased by the administration of 10 μM GTP. Alpha-MSH had no effect on cyclic AMP (cAMP) accumulation, while isoprenaline stimulated AC activity in a dose-dependent manner.
|Number of pages||4|
|Publication status||Published - Jan 1 1989|
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