Adenylate cyclase activity in homogenates of human melanoma cells. Effect of α-MSH and isoprenaline

E. Karg, L. H. Johansson, A. Hindemith-Augustsson, E. Rosengren, H. Rorsman

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Abstract

The effects of the alpha-melanocyte-stimulating hormone (α-MSH) (10-7-10-5 M) and the β-adrenoceptor agonist isoprenaline (10-9-10-4 M) on adenylate cyclase (AC) activity were investigated in homogenates of the human IGR 1 melanoma cells with or without additional GTP. Basal AC activity was increased by the administration of 10 μM GTP. Alpha-MSH had no effect on cyclic AMP (cAMP) accumulation, while isoprenaline stimulated AC activity in a dose-dependent manner.

Original languageEnglish
Pages (from-to)288-291
Number of pages4
JournalActa Dermato-Venereologica
Volume69
Issue number4
Publication statusPublished - Jan 1 1989

ASJC Scopus subject areas

  • Dermatology

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    Karg, E., Johansson, L. H., Hindemith-Augustsson, A., Rosengren, E., & Rorsman, H. (1989). Adenylate cyclase activity in homogenates of human melanoma cells. Effect of α-MSH and isoprenaline. Acta Dermato-Venereologica, 69(4), 288-291.