Adenosine signalling in diabetes mellitus-pathophysiology and therapeutic considerations

Luca Antonioli, Corrado Blandizzi, Balázs Csóka, Pál Pacher, György Haskó

Research output: Contribution to journalReview article

74 Citations (Scopus)

Abstract

Adenosine is a key extracellular signalling molecule that regulates several aspects of tissue function by activating four G-protein-coupled receptors, A 1, A 2A, A 2B and A 1 adenosine receptors. Accumulating evidence highlights a critical role for the adenosine system in the regulation of glucose homeostasis and the pathophysiology of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Although adenosine signalling is known to affect insulin secretion, new data indicate that adenosine signalling also contributes to the regulation of β-cell homeostasis and activity by controlling the proliferation and regeneration of these cells as well as the survival of β cells in inflammatory microenvironments. Furthermore, adenosine is emerging as a major regulator of insulin responsiveness by controlling insulin signalling in adipose tissue, muscle and liver; adenosine also indirectly mediates effects on inflammatory and/or immune cells in these tissues. This Review critically discusses the role of the adenosine-adenosine receptor system in regulating both the onset and progression of T1DM and T2DM, and the potential of pharmacological manipulation of the adenosinergic system as an approach to manage T1DM, T2DM and their associated complications.

Original languageEnglish
Pages (from-to)228-241
Number of pages14
JournalNature Reviews Endocrinology
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 30 2015

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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