Adenosine signalling in diabetes mellitus-pathophysiology and therapeutic considerations

Luca Antonioli, Corrado Blandizzi, Balázs Csóka, Pál Pacher, G. Haskó

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Adenosine is a key extracellular signalling molecule that regulates several aspects of tissue function by activating four G-protein-coupled receptors, A 1, A 2A, A 2B and A 1 adenosine receptors. Accumulating evidence highlights a critical role for the adenosine system in the regulation of glucose homeostasis and the pathophysiology of type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Although adenosine signalling is known to affect insulin secretion, new data indicate that adenosine signalling also contributes to the regulation of β-cell homeostasis and activity by controlling the proliferation and regeneration of these cells as well as the survival of β cells in inflammatory microenvironments. Furthermore, adenosine is emerging as a major regulator of insulin responsiveness by controlling insulin signalling in adipose tissue, muscle and liver; adenosine also indirectly mediates effects on inflammatory and/or immune cells in these tissues. This Review critically discusses the role of the adenosine-adenosine receptor system in regulating both the onset and progression of T1DM and T2DM, and the potential of pharmacological manipulation of the adenosinergic system as an approach to manage T1DM, T2DM and their associated complications.

Original languageEnglish
Pages (from-to)228-241
Number of pages14
JournalNature Reviews Endocrinology
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 30 2015

Fingerprint

Adenosine
Diabetes Mellitus
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Insulin
Therapeutics
Homeostasis
Adenosine A2B Receptors
Purinergic P1 Receptors
G-Protein-Coupled Receptors
Adipose Tissue
Regeneration
Cell Survival
Cell Proliferation
Pharmacology
Glucose
Muscles
Liver

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Adenosine signalling in diabetes mellitus-pathophysiology and therapeutic considerations. / Antonioli, Luca; Blandizzi, Corrado; Csóka, Balázs; Pacher, Pál; Haskó, G.

In: Nature Reviews Endocrinology, Vol. 11, No. 4, 30.04.2015, p. 228-241.

Research output: Contribution to journalArticle

Antonioli, Luca ; Blandizzi, Corrado ; Csóka, Balázs ; Pacher, Pál ; Haskó, G. / Adenosine signalling in diabetes mellitus-pathophysiology and therapeutic considerations. In: Nature Reviews Endocrinology. 2015 ; Vol. 11, No. 4. pp. 228-241.
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