Adenosine receptors: Therapeutic aspects for inflammatory and immune diseases

György Haskó, Joel Linden, Bruce Cronstein, Pál Pacher

Research output: Contribution to journalReview article

715 Citations (Scopus)

Abstract

Adenosine is a key endogenous molecule that regulates tissue function by activating four G-protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system express these receptors and are responsive to the modulatory effects of adenosine in an inflammatory environment. Animal models of asthma, ischaemia, arthritis, sepsis, inflammatory bowel disease and wound healing have helped to elucidate the regulatory roles of the various adenosine receptors in dictating the development and progression of disease. This recent heightened awareness of the role of adenosine in the control of immune and inflammatory systems has generated excitement regarding the potential use of adenosine-receptor-based therapies in the treatment of infection, autoimmunity, ischaemia and degenerative diseases.

Original languageEnglish
Pages (from-to)759-770
Number of pages12
JournalNature Reviews Drug Discovery
Volume7
Issue number9
DOIs
Publication statusPublished - Sep 10 2008

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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