Adenosine potentiation of neuromuscular blocking agents in guinea-pigs

K. Nitahara, P. Kornak, H. Nagashima, E. Vízi, F. F. Foldes, K. Dan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We have investigated the effects of adenosine i.v. on neuromuscular block induced by rocuronium, vecuronium and pipecuronium in an in vivo guinea-pig sciatic nerve-tibialis anterior preparation. The ED50 of each neuromuscular blocker was determined from cumulative log dose-response regression lines (n = 14). In separate experiments, adenosine 0.1 mg kg-1 min-1 or the same volume of 0.9% NaCl was given i.v. via a constant infusion and the ED50 of each neuromuscular blocking agent was then administered (n = 24). Adenosine 0.1 mg kg-1 min-1 increased significantly maximal block induced by the ED50 of these neuromuscular blockers (55-72%, 49-73% and 60-96%, respectively, for rocuronium, vecuronium and pipecuronium; P <0.05). Time to maximal block after rocuronium was significantly prolonged by adenosine (1.4-2.1 min; P <0.05) and time to maximal block after vecuronium and pipecuronium was unchanged by adenosine. Time to maximal recovery of twitch tension after administration of the ED50 of all neuromuscular blocking agents was prolonged significantly by adenosine (4.5-10.7 min, 8.2-15.8 min and 47.0-128.7 min, respectively, for rocuronium, vecuronium and pipecuronium; P <0.05). We conclude that continuous infusion of adenosine 0.1 mg kg-1 min-1 potentiated the effects of neuromuscular blocking agents in this in vivo guinea-pig preparation.

Original languageEnglish
Pages (from-to)245-247
Number of pages3
JournalBritish Journal of Anaesthesia
Volume84
Issue number2
Publication statusPublished - Feb 2000

Fingerprint

Neuromuscular Blocking Agents
Pipecuronium
Adenosine
Guinea Pigs
Vecuronium Bromide
Neuromuscular Blockade
Sciatic Nerve
rocuronium

Keywords

  • Guinea-pig
  • Neuromuscular block, pipecuronium
  • Neuromuscular block, rocuronium
  • Neuromuscular block, vecuronium
  • Pharmacology, adenosine

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Nitahara, K., Kornak, P., Nagashima, H., Vízi, E., Foldes, F. F., & Dan, K. (2000). Adenosine potentiation of neuromuscular blocking agents in guinea-pigs. British Journal of Anaesthesia, 84(2), 245-247.

Adenosine potentiation of neuromuscular blocking agents in guinea-pigs. / Nitahara, K.; Kornak, P.; Nagashima, H.; Vízi, E.; Foldes, F. F.; Dan, K.

In: British Journal of Anaesthesia, Vol. 84, No. 2, 02.2000, p. 245-247.

Research output: Contribution to journalArticle

Nitahara, K, Kornak, P, Nagashima, H, Vízi, E, Foldes, FF & Dan, K 2000, 'Adenosine potentiation of neuromuscular blocking agents in guinea-pigs', British Journal of Anaesthesia, vol. 84, no. 2, pp. 245-247.
Nitahara K, Kornak P, Nagashima H, Vízi E, Foldes FF, Dan K. Adenosine potentiation of neuromuscular blocking agents in guinea-pigs. British Journal of Anaesthesia. 2000 Feb;84(2):245-247.
Nitahara, K. ; Kornak, P. ; Nagashima, H. ; Vízi, E. ; Foldes, F. F. ; Dan, K. / Adenosine potentiation of neuromuscular blocking agents in guinea-pigs. In: British Journal of Anaesthesia. 2000 ; Vol. 84, No. 2. pp. 245-247.
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