Adenosine in the immune system

G. Haskó, Balázs Koscsó, Balázs Csóka

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Adenosine is an endogenous purine nucleoside, which is produced during metabolic stress, including inflammatory insults and tissue injury, and its extracellular level robustly increases in response to tissue damage. Extracellular adenosine orchestrates immune/inflammatory responses by activating adenosine receptors on the surface of innate and adaptive immune cells. The four adenosine receptors, A1, A2A, A2B, and A3, are G protein-coupled membrane receptors and can be expressed by every immune cell. This book chapter summarizes our knowledge about the immune modulatory effect of adenosine on immune/inflammatory responses by focusing on its effects on various immune cell populations.

Original languageEnglish
Title of host publicationAdenosine: A Key Link between Metabolism and Brain Activity
PublisherSpringer New York
Pages233-251
Number of pages19
ISBN (Print)9781461439035, 1461439027, 9781461439028
DOIs
Publication statusPublished - Nov 1 2013

Fingerprint

Adenosine
Immune System
Adenosine A2A Receptors
Purine Nucleosides
Adenosine A1 Receptors
Physiological Stress
Purinergic P1 Receptors
G-Protein-Coupled Receptors
Membranes
Wounds and Injuries
Population

Keywords

  • Asthma
  • Atherosclerosis
  • Caffeine
  • Cancer
  • Metabolic syndrome
  • Theophylline
  • Vascular

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Haskó, G., Koscsó, B., & Csóka, B. (2013). Adenosine in the immune system. In Adenosine: A Key Link between Metabolism and Brain Activity (pp. 233-251). Springer New York. https://doi.org/10.1007/978-1-4614-3903-5_12

Adenosine in the immune system. / Haskó, G.; Koscsó, Balázs; Csóka, Balázs.

Adenosine: A Key Link between Metabolism and Brain Activity. Springer New York, 2013. p. 233-251.

Research output: Chapter in Book/Report/Conference proceedingChapter

Haskó, G, Koscsó, B & Csóka, B 2013, Adenosine in the immune system. in Adenosine: A Key Link between Metabolism and Brain Activity. Springer New York, pp. 233-251. https://doi.org/10.1007/978-1-4614-3903-5_12
Haskó G, Koscsó B, Csóka B. Adenosine in the immune system. In Adenosine: A Key Link between Metabolism and Brain Activity. Springer New York. 2013. p. 233-251 https://doi.org/10.1007/978-1-4614-3903-5_12
Haskó, G. ; Koscsó, Balázs ; Csóka, Balázs. / Adenosine in the immune system. Adenosine: A Key Link between Metabolism and Brain Activity. Springer New York, 2013. pp. 233-251
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