Subtotal orchidectomy is a suitable method to induce adenomatous Leydig cell hyperplasia in the testicular remnant without irradiation or toxic chemicals. Very expressed hyperplasia of the smooth endoplasmic reticulum was detectable electronmicroscopically in the newly formed Leydig cells. The activity of Δ5-3β-hydroxysteroid dehydrogenase in the homogenate of the testicular remnant was found considerably elevated. These observations suggest a steroidogenetic activity of the proliferating Leydig cells.
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Endocrinology, Diabetes and Metabolism