Adenocarcinoma of the colon developing on the basis of Crohn's disease in childhood

L. Tiszlavicz, Marianna Kapin, A. Várkonyi, Attila Lõrincz, Katalin Bartyik, Tibor Várkonyi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Colorectal carcinoma rarely affects children and has a dismal prognosis with 5-year survival rates as low as 2.5%-7% despite apparently radical surgery. Here we report the case of an adenocarcinoma of the sigmoid colon in a 15-year-old girl preceded by uncertain abdominal complaints of 5 years' duration. Pathological work-up revealed a tumour with lymph node metastases (pT3N1). Immunohistochemical evidence of p53 overexpression by the tumour cells raised the suspicion of an underlying Li-Fraumeni syndrome. In addition, there were aphthoid ulceration, fissuration of the non-tumorous mucosa, along with a mixed transmural infiltrate composed of macrophages, eosinophils, and non-typical giant cells, which were compatible with simultaneous Crohn's disease. Anamnestic data concerning the occurrence of idiopathic inflammatory bowel disease or colorectal carcinoma in the patient's relatives were non-contributory. The present results suggest a possible relationship between Crohn's disease and colon cancer due to the defective p53 gene product.

Original languageEnglish
Pages (from-to)168-172
Number of pages5
JournalEuropean Journal of Pediatrics
Volume160
Issue number3
DOIs
Publication statusPublished - 2001

Fingerprint

Crohn Disease
Colorectal Neoplasms
Colon
Adenocarcinoma
Li-Fraumeni Syndrome
p53 Genes
Sigmoid Colon
Giant Cells
Inflammatory Bowel Diseases
Eosinophils
Colonic Neoplasms
Neoplasms
Mucous Membrane
Survival Rate
Lymph Nodes
Macrophages
Neoplasm Metastasis

Keywords

  • Childhood
  • Colonic Crohn disease
  • Colorectal carcinoma
  • p53 overexpression

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Adenocarcinoma of the colon developing on the basis of Crohn's disease in childhood. / Tiszlavicz, L.; Kapin, Marianna; Várkonyi, A.; Lõrincz, Attila; Bartyik, Katalin; Várkonyi, Tibor.

In: European Journal of Pediatrics, Vol. 160, No. 3, 2001, p. 168-172.

Research output: Contribution to journalArticle

Tiszlavicz, L. ; Kapin, Marianna ; Várkonyi, A. ; Lõrincz, Attila ; Bartyik, Katalin ; Várkonyi, Tibor. / Adenocarcinoma of the colon developing on the basis of Crohn's disease in childhood. In: European Journal of Pediatrics. 2001 ; Vol. 160, No. 3. pp. 168-172.
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