Additive effect of cyclooxygenase and nitric oxide synthase blockade on the cerebrocortical microcirculation

Zsombor Lacza, László Hortobágyi, Béla Horváth, Eszter M. Horváth, Péter Sándor, Zoltán Benyó

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The contribution of vasodilator cyclooxygenase (COX) metabolites to the maintenance of the cerebrocortical blood flow (CBF) has been studied under physiological conditions and in nitric oxide (NO) deficiency. Inhibition of COX decreased resting CBF without changing arterial blood pressure. NO synthase blockade resulted in hypertension and CBF reduction as well as in enhanced cerebral prostacyclin and prostaglandin E2 production. Despite the increased vasodilator prostanoid release in the absence of NO, the CBF-decreasing effect of COX blockade failed to increase. Therefore, the COX pathway seems to play a similar role under physiological and NO-deficient conditions in the maintenance of the resting CBF.

Original languageEnglish
Pages (from-to)1027-1031
Number of pages5
JournalNeuroreport
Volume20
Issue number11
DOIs
Publication statusPublished - Jul 15 2009

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Keywords

  • Cerebrocortical circulation
  • Cyclooxygenase
  • Nitric oxide deficiency
  • Prostacyclin
  • Prostaglandin E

ASJC Scopus subject areas

  • Neuroscience(all)

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