Additional human papillomavirus types detected by the hybrid capture tube test among samples from women with cytological and colposcopical atypia

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Abstract

The type specificity of the human papillomavirus (HPV) Hybrid Capture Tube (HCT) test was evaluated by using typing with PCR (MY09-MY11)- restriction fragment length polymorphism (RFLP) and sequencing. All samples HCT test positive for only low-risk HPV (n = 15) or only high-risk HPV (n = 102) were confirmed, whereas 9 of 12 HCT test double-positive samples contained only high-risk HPV types as determined by PCR-RFLP. Several high- risk HPV types (HPV-53, -58, -62, -66, -CP8304, and -MM4) not included in the HCT test were indeed detected, indicating a broader detection range with retained distinction between low-risk and high-risk HPV types.

Original languageEnglish
Pages (from-to)408-411
Number of pages4
JournalJournal of Clinical Microbiology
Volume38
Issue number1
Publication statusPublished - Jan 24 2000

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ASJC Scopus subject areas

  • Microbiology (medical)

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