Adaptive immunity in ankylosing spondylitis: Phenotype and functional alterations of T-cells before and during infliximab therapy

Balázs Szalay, Gergo Mészáros, Áron Cseh, Lilla Ács, Magdolna Deák, László Kovács, Barna Vásárhelyi, Attila Balog

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Our aim was to assess the phenotype of T-cell subsets in patients with ankylosing spondylitis (AS), a chronic inflammatory rheumatic disease. In addition, we also tested short-term T-cell activation characteristics. Measurements were done in 13 AS patients before and during the intravenous therapy with anti-TNF agent infliximab (IFX). Flow cytometry was used to determine T-cell subsets in peripheral blood and their intracellular signaling during activation. The prevalence of Th2 and Th17 cells responsible for the regulation of adaptive immunity was higher in AS than in 9 healthy controls. Although IFX therapy improved patients' condition, immune phenotype did not normalize. Cytoplasmic and mitochondrial calcium responses of CD4+ and CD8+ cells to a specific activation were delayed, while NO generation was increased in AS. NO generation normalized sooner upon IFX than calcium response. These results suggest an abnormal immune phenotype with functional disturbances of CD4+ and CD8+ cells in AS.

Original languageEnglish
Article number808724
JournalClinical and Developmental Immunology
Volume2012
DOIs
Publication statusPublished - Jan 1 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Adaptive immunity in ankylosing spondylitis: Phenotype and functional alterations of T-cells before and during infliximab therapy'. Together they form a unique fingerprint.

  • Cite this