Adaptive evolution of complex innovations through stepwise metabolic niche expansion

Balázs Szappanos, Jonathan Fritzemeier, Bálint Csörga, Viktória Lázár, Xiaowen Lu, Gergely Fekete, Balázs Bálint, Róbert Herczeg, István Nagy, Richard A. Notebaart, Martin J. Lercher, C. Pál, B. Papp

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A central challenge in evolutionary biology concerns the mechanisms by which complex metabolic innovations requiring multiple mutations arise. Here, we propose that metabolic innovations accessible through the addition of a single reaction serve as stepping stones towards the later establishment of complex metabolic features in another environment. We demonstrate the feasibility of this hypothesis through three complementary analyses. First, using genome-scale metabolic modelling, we show that complex metabolic innovations in Escherichia coli can arise via changing nutrient conditions. Second, using phylogenetic approaches, we demonstrate that the acquisition patterns of complex metabolic pathways during the evolutionary history of bacterial genomes support the hypothesis. Third, we show how adaptation of laboratory populations of E. coli to one carbon source facilitates the later adaptation to another carbon source. Our work demonstrates how complex innovations can evolve through series of adaptive steps without the need to invoke non-Adaptive processes.

Original languageEnglish
Article number11607
JournalNature Communications
Volume7
DOIs
Publication statusPublished - May 20 2016

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genome
Carbon
Innovation
Escherichia coli
Bacterial Genomes
expansion
carbon
nutrients
mutations
Escherichia
Metabolic Networks and Pathways
biology
acquisition
Genes
History
histories
Genome
Food
Mutation
Population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry(all)
  • Physics and Astronomy(all)

Cite this

Adaptive evolution of complex innovations through stepwise metabolic niche expansion. / Szappanos, Balázs; Fritzemeier, Jonathan; Csörga, Bálint; Lázár, Viktória; Lu, Xiaowen; Fekete, Gergely; Bálint, Balázs; Herczeg, Róbert; Nagy, István; Notebaart, Richard A.; Lercher, Martin J.; Pál, C.; Papp, B.

In: Nature Communications, Vol. 7, 11607, 20.05.2016.

Research output: Contribution to journalArticle

Szappanos, B, Fritzemeier, J, Csörga, B, Lázár, V, Lu, X, Fekete, G, Bálint, B, Herczeg, R, Nagy, I, Notebaart, RA, Lercher, MJ, Pál, C & Papp, B 2016, 'Adaptive evolution of complex innovations through stepwise metabolic niche expansion', Nature Communications, vol. 7, 11607. https://doi.org/10.1038/ncomms/11607
Szappanos B, Fritzemeier J, Csörga B, Lázár V, Lu X, Fekete G et al. Adaptive evolution of complex innovations through stepwise metabolic niche expansion. Nature Communications. 2016 May 20;7. 11607. https://doi.org/10.1038/ncomms/11607
Szappanos, Balázs ; Fritzemeier, Jonathan ; Csörga, Bálint ; Lázár, Viktória ; Lu, Xiaowen ; Fekete, Gergely ; Bálint, Balázs ; Herczeg, Róbert ; Nagy, István ; Notebaart, Richard A. ; Lercher, Martin J. ; Pál, C. ; Papp, B. / Adaptive evolution of complex innovations through stepwise metabolic niche expansion. In: Nature Communications. 2016 ; Vol. 7.
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