Adaptive evolution of bacterial metabolic networks by horizontal gene transfer

C. Pál, B. Papp, Martin J. Lercher

Research output: Contribution to journalArticle

309 Citations (Scopus)

Abstract

Numerous studies have considered the emergence of metabolic pathways, but the modes of recent evolution of metabolic networks are poorly understood. Here, we integrate comparative genomics with flux balance analysis to examine (i) the contribution of different genetic mechanisms to network growth in bacteria, (ii) the selective forces driving network evolution and (iii) the integration of new nodes into the network. Most changes to the metabolic network of Escherichia coli in the past 100 million years are due to horizontal gene transfer, with little contribution from gene duplicates. Networks grow by acquiring genes involved in the transport and catalysis of external nutrients, driven by adaptations to changing environments. Accordingly, horizontally transferred genes are integrated at the periphery of the network, whereas central parts remain evolutionarily stable. Genes encoding physiologically coupled reactions are often transferred together, frequently in operons. Thus, bacterial metabolic networks evolve by direct uptake of peripheral reactions in response to changed environments.

Original languageEnglish
Pages (from-to)1372-1375
Number of pages4
JournalNature Genetics
Volume37
Issue number12
DOIs
Publication statusPublished - Dec 2005

Fingerprint

Horizontal Gene Transfer
Metabolic Networks and Pathways
Duplicate Genes
Genes
Operon
Genomics
Catalysis
Escherichia coli
Bacteria
Food
Growth

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Adaptive evolution of bacterial metabolic networks by horizontal gene transfer. / Pál, C.; Papp, B.; Lercher, Martin J.

In: Nature Genetics, Vol. 37, No. 12, 12.2005, p. 1372-1375.

Research output: Contribution to journalArticle

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