Adaptation of 5'-deiodination to hypothyroid conditions following surgical and/or radiothyroidectomy in chickens.

P. Rudas, G. Pethes

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effect of thyroidectomy on serum levels of thyroid hormones (thyroxine, T4; triiodothyronine, T3) and on tissue levels of T3 as well as on 5'-deiodination (5'-DI) in liver, kidney and brain of chickens was investigated. The most effective way of thyroidectomy was a combined surgical (Tx) plus radiothyroidectomy (RTx) with low amounts of 131-I (NaI). The latter destroyed extra-thyroidal hormone production. It was found that even if after Tx and RTx the serum levels of T4 and T3 were close to the detection limit, the tissue T3 level was only half of normal in liver and kidney and remained normal in the brain. It is suggested that lowered 5'-deiodination is an important but not exclusive factor contributing to this adaptation of cells to hypothyroid conditions.

Original languageEnglish
Pages (from-to)227-239
Number of pages13
JournalActa veterinaria Hungarica
Volume37
Issue number3
Publication statusPublished - Dec 1 1989

ASJC Scopus subject areas

  • veterinary(all)

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