Acute toxicological experiment of T-2 toxin in rabbits.

R. Glávits, A. Ványi, S. Fekete, J. Tamás

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Rabbits were treated with a single oral dose (1, 2, 4, 6, 8, 10 or 15 mg/kg body mass) of T-2 fusariotoxin. Doses of 4 mg or higher killed the animals in 24 to 48 h. As opposed to the controls, in the treated rabbits gross pathological and histopathological examinations revealed acute catarrhal gastroenteritis, necrosis of lymphoid cells of the gastrointestinal mucosa, centrolobular dystrophy of the liver, necrosis of cells of the mononuclear phagocyte system (MPS) in the liver, tubulonephrosis, focal dystrophy of the adrenal cortex, lymphocyte depletion involving both T- and B-cell-dependent zones of the lymphoid organs (spleen, lymph, ampulla ilei), and depletion and necrosis of the myelopoietic cell colonies of the bone marrow. Similar but milder changes were observed in surviving rabbits exsanguinated 48 h after treatment. In addition to the direct damage done to the digestive tract mucosa and liver, the toxin severely damaged the cells participating in humoral and cell-mediated immunity and in the local defence of the intestinal mucosa, and markedly impaired phagocytosis and granulocytopoiesis. In another experiment rabbits were given oral doses of 2 mg/kg body mass T-2 toxin daily for several days. One rabbit was killed by bleeding every day. In rabbits killed beyond day 7 there was subacute catarrhal gastritis, emaciation, and hypertrophy of the adrenal cortex.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalActa veterinaria Hungarica
Volume37
Issue number1-2
Publication statusPublished - Dec 1 1989

ASJC Scopus subject areas

  • veterinary(all)

Fingerprint Dive into the research topics of 'Acute toxicological experiment of T-2 toxin in rabbits.'. Together they form a unique fingerprint.

  • Cite this

    Glávits, R., Ványi, A., Fekete, S., & Tamás, J. (1989). Acute toxicological experiment of T-2 toxin in rabbits. Acta veterinaria Hungarica, 37(1-2), 75-79.