Acute postnatal increase of extracellular antioxidant defence of neonates

The role of iron metabolism

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

In this study we investigated the extracellular antioxidant capacity of neonates during the first two postnatal days and its association with iron metabolism. Cord blood and blood samples at 47 ± 6 postnatal hours were taken from 10 healthy neonates and their antioxidant capacity was determined using Randox Antioxidant kits and the heme-specific antioxidant activity (HSAA). Randox indicates the chain-breaking antioxidant capacity; HSAA corresponds to the ability to limit lipid peroxidation. Iron, ferritin and transferrin levels were also measured. Randox and HSAA values were 30% higher, ferritin was 100% higher and iron was 60% lower postnatally. The amount of change in HSAA values correlated with the change in ferritin level (r=0.67, p <0.05). Conclusion: These results suggest that extracellular antioxidant capacity (both chain-breaking and heme-specific antioxidant activities) increases shortly after birth. Lower iron and higher ferritin levels could also be responsible for this phenomenon.

Original languageEnglish
Pages (from-to)1167-1170
Number of pages4
JournalActa Paediatrica, International Journal of Paediatrics
Volume90
Issue number10
DOIs
Publication statusPublished - 2001

Fingerprint

Iron
Antioxidants
Heme
Ferritins
Transferrin
Fetal Blood
Lipid Peroxidation
Parturition
CDAA

Keywords

  • Antioxidant
  • Ferritin
  • Iron
  • Lipid peroxidation
  • Neonate

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Acute postnatal increase of extracellular antioxidant defence of neonates: The role of iron metabolism",
abstract = "In this study we investigated the extracellular antioxidant capacity of neonates during the first two postnatal days and its association with iron metabolism. Cord blood and blood samples at 47 ± 6 postnatal hours were taken from 10 healthy neonates and their antioxidant capacity was determined using Randox Antioxidant kits and the heme-specific antioxidant activity (HSAA). Randox indicates the chain-breaking antioxidant capacity; HSAA corresponds to the ability to limit lipid peroxidation. Iron, ferritin and transferrin levels were also measured. Randox and HSAA values were 30{\%} higher, ferritin was 100{\%} higher and iron was 60{\%} lower postnatally. The amount of change in HSAA values correlated with the change in ferritin level (r=0.67, p <0.05). Conclusion: These results suggest that extracellular antioxidant capacity (both chain-breaking and heme-specific antioxidant activities) increases shortly after birth. Lower iron and higher ferritin levels could also be responsible for this phenomenon.",
keywords = "Antioxidant, Ferritin, Iron, Lipid peroxidation, Neonate",
author = "M. Szab{\'o} and B. V{\'a}s{\'a}rhelyi and G. Balla and T. Szab{\'o} and T. MacHay and T. Tulassay",
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T1 - Acute postnatal increase of extracellular antioxidant defence of neonates

T2 - The role of iron metabolism

AU - Szabó, M.

AU - Vásárhelyi, B.

AU - Balla, G.

AU - Szabó, T.

AU - MacHay, T.

AU - Tulassay, T.

PY - 2001

Y1 - 2001

N2 - In this study we investigated the extracellular antioxidant capacity of neonates during the first two postnatal days and its association with iron metabolism. Cord blood and blood samples at 47 ± 6 postnatal hours were taken from 10 healthy neonates and their antioxidant capacity was determined using Randox Antioxidant kits and the heme-specific antioxidant activity (HSAA). Randox indicates the chain-breaking antioxidant capacity; HSAA corresponds to the ability to limit lipid peroxidation. Iron, ferritin and transferrin levels were also measured. Randox and HSAA values were 30% higher, ferritin was 100% higher and iron was 60% lower postnatally. The amount of change in HSAA values correlated with the change in ferritin level (r=0.67, p <0.05). Conclusion: These results suggest that extracellular antioxidant capacity (both chain-breaking and heme-specific antioxidant activities) increases shortly after birth. Lower iron and higher ferritin levels could also be responsible for this phenomenon.

AB - In this study we investigated the extracellular antioxidant capacity of neonates during the first two postnatal days and its association with iron metabolism. Cord blood and blood samples at 47 ± 6 postnatal hours were taken from 10 healthy neonates and their antioxidant capacity was determined using Randox Antioxidant kits and the heme-specific antioxidant activity (HSAA). Randox indicates the chain-breaking antioxidant capacity; HSAA corresponds to the ability to limit lipid peroxidation. Iron, ferritin and transferrin levels were also measured. Randox and HSAA values were 30% higher, ferritin was 100% higher and iron was 60% lower postnatally. The amount of change in HSAA values correlated with the change in ferritin level (r=0.67, p <0.05). Conclusion: These results suggest that extracellular antioxidant capacity (both chain-breaking and heme-specific antioxidant activities) increases shortly after birth. Lower iron and higher ferritin levels could also be responsible for this phenomenon.

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KW - Ferritin

KW - Iron

KW - Lipid peroxidation

KW - Neonate

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